Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.110
Abstract: Group3 medulloblastoma (MBG3) that predominantly occur in young children are usually associated with MYC amplification and/or overexpression, frequent metastasis and a dismal prognosis. Physiologically relevant MBG3 models are currently lacking, making inferences related to their… read more here.
Keywords: embryonic cerebellar; novel myc; myc driven; driven medulloblastoma ... See more keywords
Abstract B004: An isogenic CRISPR screen identifies novel MYC-driven vulnerabilities
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.synthleth24-b004
Abstract: c-MYC (MYC) is a central regulatory protein that is dysregulated in >50% of all human cancers and is linked to aggressive disease. Developing MYC inhibitors would revolutionize cancer treatment; however, developing small molecules that directly… read more here.
Keywords: cancer; myc; myc driven; crispr screen ... See more keywords