Novel NRF2‐activated cancer treatments utilizing synthetic lethality
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DOI: 10.1002/iub.2680
Abstract: The KEAP1‐NRF2 pathway regulates the main inducible cellular response to oxidative and electrophilic stresses. Activating mutations in the KEAP1‐NRF2 pathway occur commonly in human cancer, where they contribute to the formation of aggressive tumours that… read more here.
Keywords: activated cancer; treatments utilizing; nrf2 activated; cancer treatments ... See more keywords
Structure-activity and structure-property relationships of novel Nrf2 activators with a 1,2,4-oxadiazole core and their therapeutic effects on acetaminophen (APAP)-induced acute liver injury.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.071
Abstract: The antioxidant function induced by Nrf2 protects the liver from damage. We found a novel Nrf2 activator named compound 25 via structural modification of compound 1 we previously reported. In vitro, compound 25 induced Nrf2 transport… read more here.
Keywords: liver injury; novel nrf2; acute liver; structure ... See more keywords
The Novel Nrf2 Activator Omaveloxolone Regulates Microglia Phenotype and Ameliorates Secondary Brain Injury after Intracerebral Hemorrhage in Mice
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DOI: 10.1155/2022/4564471
Abstract: The polarization of microglia is recognized as a crucial factor in reducing neuroinflammation and promoting hematoma clearance after intracerebral hemorrhage (ICH). Previous studies have revealed that redox components participate in the regulation of microglial polarization.… read more here.
Keywords: nrf2 activator; activator omaveloxolone; novel nrf2; intracerebral hemorrhage ... See more keywords