Exploration of the structure–activity relationship and druggability of novel oxazolidinone‐based compounds as Gram‐negative antibacterial agents
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900129
Abstract: To gain further knowledge of the structure–activity relationship and druggability of novel oxazolidinone‐based UDP‐3‐O‐acyl‐N‐acetylglucosamine deacetylase (LpxC) inhibitors as Gram‐negative antibacterial agents, compounds containing the hydrophobic tails with different lengths and terminal substitutions were synthesized and… read more here.
Keywords: gram negative; structure activity; novel oxazolidinone; oxazolidinone based ... See more keywords
Novel oxazolidinone zinc(II) complexes as antibacterial and anti-SARS-CoV-2 agents: synthesis, characterization, DFT calculations, ADMET, in silico molecular docking and biological activities
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Coordination Chemistry"
DOI: 10.1080/00958972.2023.2204512
Abstract: Abstract A series of Zn(II) complexes with oxazolidinone derivatives has been synthesized and characterized using spectroscopic techniques: IR, 1H NMR, UV-Vis spectroscopy, and TGA/DTG thermal investigation. Theoretical computations were carried out using B3LYP/6-31G(d) and B3LYP/LanL2DZ… read more here.
Keywords: molecular docking; oxazolidinone zinc; zinc complexes; novel oxazolidinone ... See more keywords
Development and Validation of the Chiral Liquid Chromatography Method for Separation of Enantiomeric Impurity in Novel Oxazolidinone Antibacterial Agent WCK 4086.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmy052
Abstract: A highly stereo-specific liquid chromatographic method was developed and validated for the quantification of enantiomeric impurity (R-enantiomer) in novel oxazolidinone antibacterial agent (WCK 4086), a drug substance. The separation was achieved on Chiralpak AD-H (amylose-based… read more here.
Keywords: enantiomeric impurity; wck 4086; method; novel oxazolidinone ... See more keywords
Contezolid, a novel oxazolidinone antibiotic, may improve drug-related thrombocytopenia in clinical antibacterial treatment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1157437
Abstract: One of the major limitations in the clinical use of existing oxazolidinone antibiotics is their characteristic adverse reactions, in particular thrombocytopenia. In anti-infective treatment, if patients are suspected of having drug-induced thrombocytopenia, the first step… read more here.
Keywords: contezolid novel; antibacterial treatment; novel oxazolidinone; treatment ... See more keywords