Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates
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DOI: 10.1111/nyas.14352
Abstract: Oximes remain a long‐standing element of the therapy for nerve agents, organophosphates (OPs) that poison by inhibiting the enzyme acetylcholinesterase (AChE), resulting in hypercholinergic activity both centrally and peripherally. Oximes, such as the pyridinium oxime… read more here.
Keywords: demonstrated novel; novel oxime; nerve agent; central neuroprotection ... See more keywords
Novel Oxime Synthesized from a Natural Product of Senecio nutans SCh. Bip. (Asteraceae) Enhances Vascular Relaxation in Rats by an Endothelium-Independent Mechanism
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DOI: 10.3390/molecules27103333
Abstract: Senecio nutans Sch. Bip. and its constituents are reported to have antihypertensive effects. We isolated metabolite–1, a natural compound from S. nutans (4-hydroxy-3-(isopenten-2-yl)-acetophenone), and synthesized novel oxime – 1 (4-hydroxy-3-(isopenten-2-yl)-acetophenoxime) to evaluate their effect on… read more here.
Keywords: senecio nutans; novel oxime; nutans sch; contractile response ... See more keywords