Potency and Selectivity Optimization of Tryptophanol‐Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer
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DOI: 10.1002/cmdc.202000522
Abstract: To search for novel p53 activators, four series of novel (S)‐ and (R)‐tryptophanol‐derived oxazoloisoindolinones were synthesized in a straightforward manner and their antiproliferative activity was evaluated in the human colorectal cancer HCT116 cell line. Structural optimization… read more here.
Keywords: derived oxazoloisoindolinones; novel p53; tryptophanol derived; p53 ... See more keywords