Simultaneous quantification of EVT201, a novel partial positive allosteric GABAA receptor modulator, and its two metabolites in human plasma by UHPLC/MS/MS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.06.001
Abstract: HighlightsEVT201 is a novel partial GABAA receptor agonist to treat insomnia.A sensitive and accurate UHPLC‐MS/MS method was developed to determine EVT201 and its two metabolites in human plasma.The method was successfully applied to the sample… read more here.
Keywords: gabaa receptor; novel partial; human plasma; method ... See more keywords
Occupancy of dopamine D2 and D3 receptors by a novel D3 partial agonist BP1.4979: a [11C]-(+)-PHNO PET study in humans
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0285-4
Abstract: There has been considerable interest in the development of dopamine D3 receptor (DRD3) partial agonists and antagonists for the treatment of substance use disorders. Pre-clinical evidence overwhelmingly supports the use of these drugs, but translation… read more here.
Keywords: novel partial; bp1; bp1 4979; agonist bp1 ... See more keywords
A novel partial gravity ground-based analog for rats via quadrupedal unloading.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.01083.2017
Abstract: Musculoskeletal deconditioning is a well-known consequence of microgravity. However, the effects of partial gravity, such as that experienced on the moon (0.16 g) or Mars (0.38 g), on musculoskeletal health remain relatively unexplored. Because Mars… read more here.
Keywords: ground based; novel partial; model; quadrupedal unloading ... See more keywords
A Novel Partial PPARγ Agonist Has Weaker Lipogenic Effect in Adipocytes and Stimulates GLUT4 Translocation in Skeletal Muscle Cells via AMPK-Dependent Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacology"
DOI: 10.1159/000519331
Abstract: INTRODUCTION Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are highly effective in treating insulin resistance. However, associated side effects such as weight gain due to increase in adipogenesis and lipogenesis hinder their clinical use. The aim… read more here.
Keywords: ppar; glut4 translocation; novel partial; effect ... See more keywords