Articles with "novel pharmaceutical" as a keyword



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Pharmacokinetic/pharmacodynamic assessment of a novel, pharmaceutical lipid–aspirin complex: results of a randomized, crossover, bioequivalence study

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Published in 2019 at "Journal of Thrombosis and Thrombolysis"

DOI: 10.1007/s11239-019-01933-7

Abstract: Aspirin (acetylsalicylic acid, ASA) can lead to gastrointestinal mucosal injury through disruption of its protective phospholipid bilayer. A liquid formulation of a novel pharmaceutical lipid–aspirin complex (PL-ASA) was designed to prevent this disruption. We sought… read more here.

Keywords: bioequivalence; pharmaceutical lipid; novel pharmaceutical; aspirin ... See more keywords
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Novel pharmaceutical cocrystal of lenalidomide with nicotinamide: Structural design, evaluation, and thermal phase transition study.

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Published in 2021 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2021.121394

Abstract: Lenalidomide (LDM), widely used for the treatment of transfusion-dependent anaemia, has low oral bioavailability due to its poor aqueous solubility. Herein, we selected nicotinamide (NIC) as a coformer and synthesized a novel pharmaceutical cocrystal: lenalidomide-nicotinamide… read more here.

Keywords: pharmaceutical cocrystal; novel pharmaceutical; phase transition; cocrystal lenalidomide ... See more keywords
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Novel pharmaceutical salts of cephalexin with organic counterions: structural analysis and properties

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Published in 2022 at "RSC Advances"

DOI: 10.1039/d2ra05565a

Abstract: Three novel pharmaceutical salts of cephalexin (CPX) with 2,6-dihydroxybenzoic acid (DHBA), 5-chlorosalicylic acid (CSA) and 5-sulfosalicylic acid (SSA), which were obtained and thoroughly explored by various analytical techniques, were found to be crystallized invariably in… read more here.

Keywords: organic counterions; counterions structural; cephalexin organic; salts cephalexin ... See more keywords
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SOLID-STATE PROPERTIES AND SOLUBILITY STUDIES OF NOVEL PHARMACEUTICAL COCRYSTAL OF ITRACONAZOLE

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Published in 2018 at "International Journal of Applied Pharmaceutics"

DOI: 10.22159/ijap.2018v10i5.26663

Abstract: Objective: Pharmaceutical cocrystal is a promising method to improve the solubility of active pharmaceutical ingredients (APIs). Itraconazole (ITZ) is a BCS class II antifungal drug with poor aqueous solubility, therefore an attempt was made to… read more here.

Keywords: novel pharmaceutical; solubility itz; itz; solubility ... See more keywords