PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.05.019
Abstract: Among the post-translational modifications, ADP-ribosylation has been for long time the least integrated in the scheme of the structural protein modifications affecting physiological functions. In spite of the original findings on bacterial-dependent ADP-ribosylation catalysed by… read more here.
Keywords: novel pharmacological; targets treatment; stress; stress granule ... See more keywords
Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.02.015
Abstract: Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the intracellular microenvironment, which is under the constitutive control of glutathione peroxidase 4 (GPX4). Ferrous iron (Fe2+) accumulation and lipid peroxidation are… read more here.
Keywords: novel pharmacological; mechanism anti; ferroptosis; ferroptosis novel ... See more keywords
Nuclear G-protein-coupled receptors as putative novel pharmacological targets.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.09.003
Abstract: Cell surface G-protein-coupled receptors (GPCRs) are targets for ˜30% of drugs currently on the market, and are the largest group of gene products targeted by drugs. Until recently, signaling mediated by GPCRs was thought to… read more here.
Keywords: novel pharmacological; protein coupled; pharmacological targets; coupled receptors ... See more keywords
Translation from animal studies of novel pharmacological therapies to clinical trials in cardiac arrest: A systematic review.
Sign Up to like & getrecommendations! Published in 2020 at "Resuscitation"
DOI: 10.1016/j.resuscitation.2020.10.028
Abstract: BACKGROUND There is a lack of new promising therapies to improve the dismal outcomes from cardiac arrest. The objectives of this study were: (1) To identify novel pharmacological therapies investigated in experimental animal studies and… read more here.
Keywords: experimental animal; animal studies; novel pharmacological; cardiac arrest ... See more keywords
An update on novel pharmacological agents for primary sclerosing cholangitis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2030707
Abstract: ABSTRACT Introduction Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disease with heterogeneous phenotypes that may lead to liver transplantation and/or end-stage liver disease. Its multifactorial etiopathogenesis remains uncertain, but gut–liver axis and bile… read more here.
Keywords: sclerosing cholangitis; novel pharmacological; update novel; primary sclerosing ... See more keywords
Prostate cancer and novel pharmacological treatment options–what’s new for 2022?
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2023.2181783
Abstract: ABSTRACT Introduction Androgen deprivation therapy (ADT) plus Androgen Receptor Target Agents (ARTAs) or docetaxel are the actual standard of care in prostate cancer (PC). Several therapeutic options are available for pretreated patients: cabazitaxel, olaparib, and… read more here.
Keywords: pharmacological treatment; prostate cancer; prostate; cancer novel ... See more keywords
Novel Pharmacological Options in the Treatment of Cholangiocarcinoma: Mechanisms of Resistance
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13102358
Abstract: Simple Summary Cholangiocarcinoma, a tumor derived from epithelial cells of the biliary tree, is characterized by a dismal prognosis. Its late diagnosis, which makes surgical resection not an option for most patients, and its marked… read more here.
Keywords: mechanisms resistance; novel pharmacological; pharmacological options; cholangiocarcinoma ... See more keywords
Novel Pharmacological Treatment Options in Pediatric Glioblastoma—A Systematic Review
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14112814
Abstract: Simple Summary Childhood glioblastoma is an aggressive brain tumor in children that has a very poor prognosis. Standard therapy includes surgery, irradiation and chemotherapy with temozolomide. So far, there is no effective drug treatment for… read more here.
Keywords: pharmacological treatment; novel pharmacological; systematic review; treatment options ... See more keywords