Hit discovery of novel 2‐phenyl‐substituted 4‐amino–6,7‐dihydro‐5H‐cyclopenta[d]pyrimidines as potential anti‐glioblastoma therapeutics: Design, synthesis, biological evaluation, and computational screening
Sign Up to like & getrecommendations! Published in 2023 at "Drug Development Research"
DOI: 10.1002/ddr.22046
Abstract: Glioblastoma multiforme (GBM) is a highly‐aggressive, dreadful disease with poor prognosis and disappointing clinical success. There is an unmet medical need of molecularly‐targeted therapeutics for GBM treatment. In the present work, a series of novel… read more here.
Keywords: glioblastoma; dihydro cyclopenta; novel phenyl; amino dihydro ... See more keywords
Synthesis and biological evaluation of novel N-(5-phenyl-1H-pyrazol-3-yl)benzenesulfonamide derivatives as potential BRAFV600E inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1957-z
Abstract: A series of novel N-(5-phenyl-1H-pyrazol-3-yl)benzenesulfonamide derivatives (5a–5l) were synthesized and developed as potential BRAFV600E inhibitors. Among them, compound 5l exhibited the most potent inhibitory activity with an IC50 value of 0.18 μM for BRAFV600E. Antiproliferative assay… read more here.
Keywords: benzenesulfonamide derivatives; potential brafv600e; brafv600e; novel phenyl ... See more keywords
Novel 2-phenyl-3-(Pyridin-2-yl) thiazolidin-4-one derivatives as potent inhibitors for proliferation of osteosarcoma cells in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.114010
Abstract: Due to unknown pathogenesis and unidentified drug target, no drug for the treatment of osteosarcoma (OS) has been launched to the market. Herein, thiazolidinone 1a was discovered as a hit compound by phenotypic screening with… read more here.
Keywords: derivatives potent; one derivatives; phenyl pyridin; thiazolidin one ... See more keywords
Synthesis and Physicochemical Properties of Novel Phenyl-Containing Sulfobetaine Surfactants
Sign Up to like & getrecommendations! Published in 2019 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.9b01907
Abstract: A novel series of sulfobetaine surfactants, 3-((4-(alkoxy)-3,5-dimethylbenzyl) dimethylammonio)-2-hydroxy-propane-1-sulfonate (CnOBSb, n = 12, 14, and 16), were synthesized for the first time. The chemical structures of products were characterized by high-resolution mass spectra, 1H NMR, and… read more here.
Keywords: physicochemical properties; properties novel; phenyl containing; sulfobetaine surfactants ... See more keywords
Design, Synthesis and Molecular Docking Study of Novel 3-Phenyl-β-Alanine-Based Oxadiazole Analogues as Potent Carbonic Anhydrase II Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030816
Abstract: Carbonic anhydrase-II (CA-II) is strongly related with gastric, glaucoma, tumors, malignant brain, renal and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. With an aim to develop… read more here.
Keywords: molecular docking; phenyl alanine; carbonic anhydrase; novel phenyl ... See more keywords