Novel platform for the multidimensional analysis of magnetic nanoparticles
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Magnetism and Magnetic Materials"
DOI: 10.1016/j.jmmm.2020.167443
Abstract: Abstract The success of Magnetic Particle Imaging (MPI) as a clinical imaging modality is inextricably linked to the availability of purpose-build magnetic nanoparticles (MNP). Attempts to develop MNP with tailored properties and predictable MPI-performance are… read more here.
Keywords: analysis magnetic; platform multidimensional; novel platform; multidimensional analysis ... See more keywords
Abstract 1525: A novel platform for protein engineering and modification to expand the therapeutic index of anti-tumor therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1525
Abstract: Purpose: A key challenge in cancer drug development is optimizing the therapeutic index (TI), a measure of a treatment’s antitumor efficacy and its toxicity, such that the agent is effective in targeting the tumor with… read more here.
Keywords: novel platform; therapeutic index; tumor; engineering ... See more keywords
DNA bridges: A novel platform for single-molecule sequencing and other DNA-protein interaction applications
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0260428
Abstract: DNA molecular combing is a technique that stretches thousands of long individual DNA molecules (up to 10 Mbp) into a parallel configuration on surface. It has previously been proposed to sequence these molecules by synthesis.… read more here.
Keywords: dna molecules; dna; bridges novel; dna bridges ... See more keywords
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202215997
Abstract: A small but significant proportion of COVID‐19 patients develop life‐threatening cytokine storm. We have developed a new anti‐inflammatory drug, EXO‐CD24, a combination of an immune checkpoint (CD24) and a delivery platform (exosomes). CD24 inhibits the… read more here.
Keywords: platform attenuating; novel platform; exo cd24; covid ... See more keywords
3D tumor explant as a novel platform to investigate therapeutic pathways and predictive biomarkers in cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1068091
Abstract: Immunotherapy with immune checkpoint inhibitors can induce durable clinical responses in different human malignancies but the number of responding patients remains globally modest. The limited therapeutic efficacy of ICI depends on multiple factors, among which… read more here.
Keywords: immune checkpoint; novel platform; explant novel; tumor explant ... See more keywords