Semi‐synthesis, antibacterial activity, and molecular docking study of novel pleuromutilin derivatives bearing cinnamic acids moieties
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800266
Abstract: To develop new antibiotics owning a special mechanism, we used the molecular assembly method to synthesize a series of novel pleuromutilin derivatives containing a cinnamic acid scaffold at the C‐14 side chain. We evaluated their… read more here.
Keywords: study; antibacterial activity; pleuromutilin derivatives; activity ... See more keywords
Synthesis and antibacterial activities of novel pleuromutilin derivatives with a substituted pyrimidine moiety.
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DOI: 10.1016/j.ejmech.2016.11.054
Abstract: The alarming growth of multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) has become a major global health hazard. Therefore, urgent demand for new antibiotics with a unique mechanism of action… read more here.
Keywords: derivatives substituted; synthesis antibacterial; pleuromutilin derivatives; antibacterial activities ... See more keywords
Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection
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DOI: 10.3390/molecules27030931
Abstract: A series of novel pleuromutilin derivatives containing nitrogen groups on the side chain of C14 were synthesized under mild conditions. Most of the synthesized derivatives displayed potent antibacterial activities. Compound 9 was found to be… read more here.
Keywords: compound; potent antibacterial; novel pleuromutilin; pleuromutilin derivatives ... See more keywords