Articles with "novel pola1" as a keyword



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Antitumor activity of novel POLA1-HDAC11 dual inhibitors.

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Published in 2021 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2021.113971

Abstract: Hybrid molecules targeting simultaneously DNA polymerase α (POLA1) and histone deacetylases (HDACs) were designed and synthesized to exploit a potential synergy of action. Among a library of screened molecules, MIR002 and GEM144 showed antiproliferative activity… read more here.

Keywords: activity novel; novel pola1; mir002 gem144; antitumor activity ... See more keywords