Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors.
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DOI: 10.1016/j.ejmech.2016.10.003
Abstract: FGF receptors (FGFRs) are tyrosine kinases that are overexpressed in diverse tumors by genetic alterations such as gene amplifications, somatic mutations and translocations. Owing to this characteristic, FGFRs are attractive targets for cancer treatment. It… read more here.
Keywords: novel ponatinib; activity; discovery novel; ponatinib analogues ... See more keywords