Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies
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DOI: 10.1021/acsmedchemlett.9b00666
Abstract: An agonist–antagonist switching strategy was performed to discover novel PPARα antagonists. Phenyldiazenyl derivatives of fibrates were developed, bearing sulfonimide or amide functional groups. A second series of compounds was synthesized, replacing the phenyldiazenyl moiety with… read more here.
Keywords: amide derivatives; novel ppar; ppar antagonists; sulfonimide amide ... See more keywords
Virtual identification of novel PPARα/γ dual agonists by scaffold hopping of saroglitazar
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1392363
Abstract: The thiazolidinedione class PPARγ agonists as antidiabetic agents are restricted in clinical use because of the side effects such as edema, weight gain, and heart failure. The single and selective agonism of PPARγ is the… read more here.
Keywords: ppar; ppar dual; novel ppar; scaffold hopping ... See more keywords