Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205573
Abstract: Polycomb repressive complex 1 (PRC1) is an essential epigenetic regulator that mainly controls histone H2A Lys119 mono-ubiquitination (H2AK119ub). BMI1 and RING1B are PRC1 core components and play critical roles in the development of various cancers.… read more here.
Keywords: bmi1 ring1b; protein complex; prc1; degradation ... See more keywords
A novel protein tyrosine phosphatase like phytase from Lactobacillus fermentum NKN51: Cloning, characterization and application in mineral release for food technology applications.
Sign Up to like & getrecommendations! Published in 2018 at "Bioresource technology"
DOI: 10.1016/j.biortech.2017.10.106
Abstract: A novel protein tyrosine phosphatase like phytase (PTPLP), designated as PhyLf from probiotic bacterium Lactobacillus fermentum NKN51 was identified, cloned, expressed and characterized. The recombinant PhyLf showed specific activity of 174.5 U/mg. PhyLf exhibited strict specificity… read more here.
Keywords: phosphatase like; phylf; novel protein; tyrosine phosphatase ... See more keywords
Proteogenomics Integrating Novel Junction Peptide Identification Strategy Discovers Three Novel Protein Isoforms of Human NHSL1 and EEF1B2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00373
Abstract: In eukaryotes, alternative pre-mRNA splicing allows a single gene to encode different protein isoforms that function in many biological processes, and they are used as biomarkers or therapeutic targets for diseases. Although protein isoforms in… read more here.
Keywords: protein; novel protein; novel junction; isoforms human ... See more keywords
In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions
Sign Up to like & getrecommendations! Published in 2019 at "Xenobiotica"
DOI: 10.1080/00498254.2018.1514545
Abstract: Abstract A 1,2,4-oxadiazole ring-containing compound DS-8500a was developed as a novel G protein-coupled receptor 119 agonist. In vivo metabolic fates of [14C]DS-8500a differently radiolabeled in the benzene ring or benzamide side carbon in rats were… read more here.
Keywords: oxadiazole ring; novel protein; protein coupled; coupled receptor ... See more keywords
From De Novo to “De Nono”: The Majority of Novel Protein-Coding Genes Identified with Phylostratigraphy Are Old Genes or Recent Duplicates
Sign Up to like & getrecommendations! Published in 2018 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evy231
Abstract: Abstract The evolution of novel protein-coding genes from noncoding regions of the genome is one of the most compelling pieces of evidence for genetic innovations in nature. One popular approach to identify de novo genes… read more here.
Keywords: novel protein; novo genes; phylostratigraphy; protein coding ... See more keywords
A proteomics approach to identifying novel protein targets involved in erinacine A–mediated inhibition of colorectal cancer cells’ aggressiveness
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13004
Abstract: Erinacine A, a major active component of a diterpenoid derivative isolated from Hericium erinaceus mycelium, has been demonstrated to exert anticancer effects. Herein, we present an investigation of the molecular mechanism of erinacine A induction… read more here.
Keywords: pi3k mtor; novel protein; erinacine; cancer cells ... See more keywords
A Novel Protein Elicitor (PELL1) Extracted from Lecanicillium lecanii Induced Resistance against Bemisia tabaci (Hemiptera: Aleyrodidae) in Gossypium hirsutum L
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/3097521
Abstract: Protein elicitors play a key role in signaling or displaying plant defense mechanism and emerging as vital tools for biocontrol of insects. This study was aimed at the characterization of the novel protein elicitor isolated… read more here.
Keywords: elicitor; protein elicitor; bemisia tabaci; lecanicillium lecanii ... See more keywords
Abstract 4402: CHTM1, a novel protein linked to cellular metabolism and human malignancy
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4402
Abstract: Several lines of emerging evidence indicate that alterations in metabolism are linked to pathogenesis of human malignancies. However, more studies are needed to completely understand the link between tumorigenesis and metabolism. In this context, we… read more here.
Keywords: chtm1; metabolism; novel protein; cellular metabolism ... See more keywords
A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer"
DOI: 10.1186/s12943-021-01457-w
Abstract: Background Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a microRNA sponge or a scaffold to interact with… read more here.
Keywords: novel protein; circaxin1; axin1 295aa; gastric cancer ... See more keywords
Application of BisANS fluorescent dye for developing a novel protein assay
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0215863
Abstract: In many biology- and chemistry-related research fields and experiments the quantification of the peptide and/or protein concentration in samples are essential. Every research environment has unique requirements, e.g. metal ions, incubation times, photostability, pH, protease… read more here.
Keywords: novel protein; application bisans; protein assay; fluorescent dye ... See more keywords
Method for Identifying Essential Proteins by Key Features of Proteins in a Novel Protein-Domain Network
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.708162
Abstract: In recent years, due to low accuracy and high costs of traditional biological experiments, more and more computational models have been proposed successively to infer potential essential proteins. In this paper, a novel prediction method… read more here.
Keywords: novel protein; domain network; essential proteins; protein domain ... See more keywords