Design, synthesis and biological evaluation of novel pteridinone derivatives as potent dual inhibitors of PLK1 and BRD4
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DOI: 10.1039/d0nj03477k
Abstract: To develop novel simultaneous inhibition of PLK1 and BRD4 bromodomain by a single molecule, three series of novel pteridinone derivatives were designed, synthesized and evaluated for their biological activity. Most compounds exhibited moderate to excellent… read more here.
Keywords: design synthesis; cell lines; plk1 brd4; pteridinone derivatives ... See more keywords