Structure-activity relationships in fungal nucleobases transporters as dissected by the inhibitory effects of novel purine analogues.
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DOI: 10.1016/j.ejmech.2018.06.038
Abstract: We have previously rationally designed, synthesized and tested a number of 3-deazapurine analogues, which inhibit the ubiquitous fungal nucleobase transporter FcyB, through binding in its major substrate binding site, by specifically interacting with Asn163. Here,… read more here.
Keywords: activity relationships; novel purine; structure activity; activity ... See more keywords