Design, Synthesis and Evaluation of Antifungal Activity of Novel Pyrazole-thiazole Carboxamides as Succinate Dehydrogenase Inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c00062
Abstract: Succinate dehydrogenase (SDH) is regarded as a promising target for fungicide discovery. To continue our ongoing studies on the discovery of novel SDH inhibitors as fungicides, novel pyrazole-thiazole carboxamides were designed, synthesized, and evaluated for… read more here.
Keywords: pyrazole thiazole; thiazole carboxamides; novel pyrazole; antifungal activity ... See more keywords
Discovery of Novel Pyrazole Amides as Potent Fungicide Candidates and Evaluation of Their Mode of Action.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c00092
Abstract: A rational molecule design strategy based on scaffold hopping was applied to discover novel leads, and then a series of novel pyrazole amide derivatives were designed, synthesized, characterized, and evaluated for their antifungal activities. Bioassay… read more here.
Keywords: discovery novel; pyrazole amides; amides potent; defense ... See more keywords
Novel Pyrazole Amides as Potential 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.
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DOI: 10.1021/acs.jafc.2c02123
Abstract: 4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an important target for the development of new herbicides. HPPD inhibitors can hinder photosynthesis and induce weed death with bleaching symptoms. To explore the novel skeleton of HPPD inhibitors, a series… read more here.
Keywords: pyrazole amides; hppd; novel pyrazole; hydroxyphenylpyruvate dioxygenase ... See more keywords
Synthesis of novel pyrazole incorporating a coumarin moiety (PC) for selective and sensitive Co2+ detection
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DOI: 10.1039/c9nj02176k
Abstract: An efficient regioselective synthesis of a novel pyrazole derivative containing a coumarin moiety was achieved, which was electrodeposited as PC/Nafion/GCE sensor probe to detect the selective Co2+ ions for the safety of environment and healthcare… read more here.
Keywords: novel pyrazole; co2; coumarin moiety; synthesis novel ... See more keywords
Synthesis, evaluation, molecular dynamics simulation and targets identification of novel pyrazole-containing imide derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1745284
Abstract: Abstract A new series of novel pyrazole-containing imide derivatives were synthesized and evaluated for their anticancer activities against A-549, Bel7402, and HCT-8 cell lines. Among these compounds A2, A4, A11 and A14 possessed high inhibition… read more here.
Keywords: molecular dynamics; pyrazole containing; containing imide; imide derivatives ... See more keywords