Novel Pyridine‐Containing Sultones: Structure‐Activity Relationship and Biological Evaluation as Selective AChE Inhibitors for the Treatment of Alzheimer's disease
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DOI: 10.1002/cmdc.202100272
Abstract: Novel pyridine‐containing sultones were synthesized and evaluated for their cholinesterase (ChE) inhibitory activity. Most of compounds showed selective acetylcholinesterase (AChE) inhibitory activity. The structure‐activity relationship (SAR) showed: (i) the fused pyridine‐containing sultones increase AChE inhibition,… read more here.
Keywords: ache; novel pyridine; containing sultones; pyridine containing ... See more keywords
Novel Pyridine Derivatives as 5‑HT2A Agonists for Treating Psychiatric Disorders.
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DOI: 10.1021/acsmedchemlett.5c00244
Abstract: Provided herein are novel pyridine derivatives as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating psychiatric disorders, and processes for preparing such compounds. read more here.
Keywords: psychiatric disorders; ht2a agonists; novel pyridine; pyridine derivatives ... See more keywords
Synthesis, Characterization and Cytotoxicity Evaluation of Some Novel Pyridine Derivatives.
Sign Up to like & getrecommendations! Published in 2018 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2018.4294
Abstract: Reaction of isonicotinaldehyde with 2-cyanoacetohydrazide afforded (E)-2-cyano-N'-(pyridin-4-ylmethylene)acetohydrazide (1). Compound 1 was used as the precursor for the synthesis of novel pyridine derivatives by reaction with different arylidene malononitriles, malononitrile and acetylacetone to give pyridine derivatives… read more here.
Keywords: novel pyridine; pyridine; pyridine derivatives; characterization cytotoxicity ... See more keywords