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Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100272
Abstract: Novel pyridine‐containing sultones were synthesized and evaluated for their cholinesterase (ChE) inhibitory activity. Most of compounds showed selective acetylcholinesterase (AChE) inhibitory activity. The structure‐activity relationship (SAR) showed: (i) the fused pyridine‐containing sultones increase AChE inhibition,…
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Keywords:
ache;
novel pyridine;
containing sultones;
pyridine containing ... See more keywords
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Published in 2018 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2018.4294
Abstract: Reaction of isonicotinaldehyde with 2-cyanoacetohydrazide afforded (E)-2-cyano-N'-(pyridin-4-ylmethylene)acetohydrazide (1). Compound 1 was used as the precursor for the synthesis of novel pyridine derivatives by reaction with different arylidene malononitriles, malononitrile and acetylacetone to give pyridine derivatives…
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Keywords:
novel pyridine;
pyridine;
pyridine derivatives;
characterization cytotoxicity ... See more keywords