Antiparasitic activities of novel pyrimidine N‐acylhydrazone hybrids
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21745
Abstract: In this article, a series of 29 new pyrimidine N‐acylhydrazone hybrids were synthesized and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi protozoa that cause the neglected diseases cutaneous leishmaniasis and Chagas disease, respectively.… read more here.
Keywords: antiparasitic activities; activities novel; novel pyrimidine; acylhydrazone hybrids ... See more keywords
Novel pyrimidine-pyridine hybrids: Synthesis, cyclooxygenase inhibition, anti-inflammatory activity and ulcerogenic liability.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.01.028
Abstract: Some derivatives containing pyrido[2,3-d:6,5d']dipyrimidine-4,5-diones (9a-f), tetrahydropyrido[2,3-d]pyrimidine-6-carbonitriles (11a-c) and 6-(4-acetylphenyl)-2-thioxo-2,3,5,6,7,8-hexahydro-1H-pyrimido[4,5-d]pyrimidin-4-one (12) were synthesized from 6-amino-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (8). The anti-inflammatory effect of these candidates was determined and the ulcer indices were calculated for active compounds. 7-Amino-5-(3,4,5-trimethoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido[2,3-d] pyrimidine-6-carbonitrile (11c)… read more here.
Keywords: anti inflammatory; ulcerogenic liability; inhibition; novel pyrimidine ... See more keywords
Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2017.12.015
Abstract: OBJECTIVE Pathologically increased activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and the associated Ca2+-leak from the sarcoplasmic reticulum are recognized to be important novel pharmacotherapeutic targets in heart failure and cardiac arrhythmias. However, CaMKII-inhibitory compounds… read more here.
Keywords: camkii inhibitor; pyrimidine based; novel pyrimidine; ca2 ... See more keywords
Synthesis and radiolabelled evaluation of novel pyrimidine derivatives as dual α-amylase inhibitors and GIT-targeted molecular imaging probe
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DOI: 10.1039/d5ra04955e
Abstract: This study successfully developed synthetic pathways for novel pyrimidine-based compounds for their potential anti-diabetic α-amylase inhibitory activity, aiming at potential antidiabetic applications. Molecular docking techniques showed that compounds 1, 6, and 8 showed the highest… read more here.
Keywords: amylase; probe; compound; novel pyrimidine ... See more keywords
Design and Optimization of Novel Pyrimidine-Morpholine Hybrids Through Computational Approaches for SRC Kinase Inhibitory Activity
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DOI: 10.1055/a-2554-1119
Abstract: Abstract Src (non receptor tyrosine kinase) plays a role in multiple pathways leading to tumor survival, proliferation and metastasis. Inhibiting Src kinase would be a therapeutic benefit in Src dependent cancers. Most of the nitrogen… read more here.
Keywords: src kinase; morpholine hybrids; novel pyrimidine; pyrimidine morpholine ... See more keywords
Novel pyrimidine-substituted chalcones: In vitro antioxidant properties and cytotoxic effects against human cancer cell lines
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DOI: 10.1371/journal.pone.0334620
Abstract: A series of novel pyrimidine-substituted chalcones were synthesized, purified, and characterized. Four selected compounds (CFMPY 4, 15, 17, and 28) exhibited modest antioxidant activity across six In vitro radical scavenging assays. The In vitro cytotoxic… read more here.
Keywords: cell lines; substituted chalcones; novel pyrimidine; pyrimidine substituted ... See more keywords
Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.922813
Abstract: In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal (B. cinereal), Botryosphaeria dothidea (B. dothidea), and Phomopsis sp. were determined using the… read more here.
Keywords: antifungal activity; derivatives bearing; pyrimidine derivatives; bearing thiadiazole ... See more keywords
Design, Synthesis and Bioactivity of Novel Pyrimidine Sulfonate Esters Containing Thioether Moiety
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054691
Abstract: Pesticides play an important role in crop disease and pest control. However, their irrational use leads to the emergence of drug resistance. Therefore, it is necessary to search for new pesticide-lead compounds with new structures.… read more here.
Keywords: design synthesis; sulfonate; activity; synthesis bioactivity ... See more keywords
Synthesis and Molecular Docking Study of Novel Pyrimidine Derivatives against COVID-19
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020739
Abstract: A novel series of pyrido[2,3-d]pyrimidines; pyrido[3,2-e][1,3,4]triazolo; and tetrazolo[1,5-c]pyrimidines were synthesized via different chemical transformations starting from pyrazolo[3,4-b]pyridin-6-yl)-N,N-dimethylcarbamimidic chloride 3b (prepared from the reaction of o-aminonitrile 1b and phosogen iminiumchloride). The structures of the newly synthesized… read more here.
Keywords: molecular docking; docking study; synthesis molecular; docking ... See more keywords