Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.
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DOI: 10.1021/acs.jmedchem.1c00621
Abstract: Due to the poor permeability across Gram-negative bacterial membranes and the troublesome bacterial efflux mechanism, only a few GyrB/ParE inhibitors with potent activity against Gram-negative pathogens have been reported. Among them, pyrimido[4,5-b]indole derivatives represented by… read more here.
Keywords: gram negative; novel pyrimido; indole derivatives; multidrug resistant ... See more keywords