Synthesis of novel 3-(quinazol-2-yl)-quinolines via SNAr and aluminum chloride-induced (hetero) arylation reactions and biological evaluation as proteasome inhibitors
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DOI: 10.1016/j.tetlet.2020.151805
Abstract: Abstract A new series of 3-(quinazol-2-yl)-quinolines was synthesized by SNAr reaction from easily prepared 4-chloro-2-(2-chloroquinolin-3-yl)quinazolines and a range of phenols and thiophenol as nucleophiles. The AlCl3-mediated C C bond formation was also successfully exploited to… read more here.
Keywords: quinazol; synthesis novel; proteasome; novel quinazol ... See more keywords