Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2118735
Abstract: Abstract Nineteen new quinazolin-4(3H)-one derivatives 3a–g and 6a–l were designed and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds was tested in vitro against 60 different human cell lines. The most potent… read more here.
Keywords: design synthesis; cell; novel quinazolinone; activity ... See more keywords
Synthesis, antimicrobial evaluation and docking studies of some novel quinazolinone Schiff base derivatives
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DOI: 10.4103/1735-5362.228942
Abstract: The quinazolin-4(3H)-one structural motif possesses a wide spectrum of biological activities. DNA gyrase play an important role in induction of bacterial death. It has been shown that many quinazolin-4(3H)-one derivatives have antibacterial effects through inhibition… read more here.
Keywords: novel quinazolinone; dna gyrase; base derivatives; quinazolinone schiff ... See more keywords
Synthesis and cytotoxic evaluation of novel quinazolinone derivatives as potential anticancer agents
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DOI: 10.4103/1735-5362.236838
Abstract: Nitrogen-rich heterocyclic compounds represent a unique class of chemicals with especial properties and have been modified to design novel pharmaceutically active compounds. In this study, a series of novel quinazolinone derivatives with substituted quinoxalindione were… read more here.
Keywords: quinazolinone derivatives; novel quinazolinone; cell lines; cytotoxic evaluation ... See more keywords
Design, synthesis and biological evaluation of some novel quinazolinone derivatives as potent apoptotic inducers.
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DOI: 10.4155/fmc-2017-0284
Abstract: AIM Novel quinazolinone and triazinoquinazolinone derivatives were designed and synthesized as apoptotic inducers. METHODOLOGY/RESULTS Most of the synthesized compounds showed excellent antiproliferative activity against MCF-7 and HCT-116 cell lines, respectively. Compounds 7a, 8a, 8d, 14a… read more here.
Keywords: hct 116; potent apoptotic; novel quinazolinone; apoptotic inducers ... See more keywords