Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety
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DOI: 10.1002/jhet.2645
Abstract: 7-Amino-3-phenyl-[1,2,4]triazolo [4,3-a] pyrimidin-5(1H)-one () was utilized as key intermediate for the synthesis of some new, quinolines and , acrylonitrile and , coumarin , and pyrazoles incorporating triazolopyrimidines. The structures of the newly synthesized compounds were… read more here.
Keywords: activity novel; antimicrobial activity; novel quinoline; quinoline chromene ... See more keywords
Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01755
Abstract: A series of novel quinoline-chalcone derivatives were designed, synthesized, and evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most potent activity with IC50 values ranging from 0.009 to 0.016 μM in a… read more here.
Keywords: chalcone derivatives; quinoline chalcone; novel quinoline; discovery novel ... See more keywords
Novel Quinoline Compound Derivatives of NSC23925 as Potent Reversal Agents Against P-Glycoprotein-Mediated Multidrug Resistance
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DOI: 10.3389/fchem.2019.00820
Abstract: Multidrug resistance is a serious problem and a common cause of cancer treatment failure, leading to patient death. Although numerous reversal resistance inhibitors have been evaluated in preclinical or clinical trials, efficient and low-toxicity reversal… read more here.
Keywords: quinoline compound; reversal agents; novel quinoline; resistance ... See more keywords