Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24060
Abstract: Remyelination is a regenerative process that restores the lost neurological function and partially depends on oligodendrocyte differentiation. Differentiation of oligodendrocytes spontaneously occurs after demyelination, depending on the cell intrinsic mechanisms. By combining a loss‐of‐function genomic… read more here.
Keywords: oligodendrocyte differentiation; remyelination; novel regulator; differentiation ... See more keywords
MK5: A novel regulator of cardiac fibroblast function?
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DOI: 10.1002/iub.1677
Abstract: MAP kinase‐activated protein kinases (MKs), protein serine/threonine kinases downstream of the MAPKs, regulate a number of biological functions. MK5 was initially identified as a substrate for p38 MAPK but subsequent studies revealed that MK5 activity… read more here.
Keywords: function mk5; novel regulator; mk5 novel; cardiac ... See more keywords
NINJ2- A novel regulator of endothelial inflammation and activation.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.04.011
Abstract: Previous genetic studies suggested that variants in NINJ2 (encode ninjurin2) confer risk to ischemic stroke or large artery atherosclerotic stroke. However, the underlying mechanisms of NINJ2 in ischemic stroke or atherosclerosis are still unknown. In… read more here.
Keywords: inflammation activation; novel regulator; inflammation; endothelial inflammation ... See more keywords
PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14842
Abstract: Phosphoinositide 3‐kinases (PI3Ks) are a family of enzymes phosphorylating phospholipids in the membrane, thereby, promoting the PI3K/AKT signaling cascade. PI3Ks are involved in a variety of fundamental cellular functions, including tumor necrosis factor α (TNFα)‐induced… read more here.
Keywords: pi3k; regulator tnf; tnf induced; tnf ... See more keywords
Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007904
Abstract: Key Points • A CRISPR/Cas9 screen targeting RNA binding proteins identifies RBM12 as a novel HbF regulator.• RBM12-mediated HbF repression is BCL11A-independent and reliant on its RRM1 domain. read more here.
Keywords: characterization rbm12; novel regulator; identification characterization; regulator ... See more keywords
HIPK2 as a Novel Regulator of Fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15041059
Abstract: Simple Summary Fibrosis can affect almost every organ and represents an increasing cause of morbidity and mortality worldwide. Despite significant progress in our understanding of the pathobiology of fibrosis, there is still a lack of… read more here.
Keywords: hipk2 novel; hipk2; novel regulator; regulator fibrosis ... See more keywords