Multiomic Analysis of Neurons with Divergent Projection Patterns Identifies Novel Regulators of Axon Pathfinding
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200615
Abstract: Axon pathfinding is a key step in neural circuits formation. However, the transcriptional mechanisms regulating its progression remain poorly understood. The binary decision of crossing or avoiding the midline taken by some neuronal axons during… read more here.
Keywords: analysis neurons; neurons divergent; multiomic analysis; regulators axon ... See more keywords
Circular RNAs as novel regulators of β-cell functions in normal and disease conditions
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.01.010
Abstract: Objective There is strong evidence for an involvement of different classes of non-coding RNAs, including microRNAs and long non-coding RNAs, in the regulation of β-cell activities and in diabetes development. Circular RNAs were recently discovered… read more here.
Keywords: circular rnas; coding rnas; non coding; rnas novel ... See more keywords
Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2019.07.004
Abstract: The regulated dynamic transport of materials among organelles through endomembrane trafficking pathways is essential for plant growth, development, and environmental adaptation, and thus is a major topic of plant biology research. Large-scale chemical library screens… read more here.
Keywords: plant endomembrane; plant; endomembrane trafficking; biology ... See more keywords
iTARGEX analysis of yeast deletome reveals novel regulators of transcriptional buffering in S phase and protein turnover
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab555
Abstract: Abstract Integrating omics data with quantification of biological traits provides unparalleled opportunities for discovery of genetic regulators by in silico inference. However, current approaches to analyze genetic-perturbation screens are limited by their reliance on annotation… read more here.
Keywords: phase; protein turnover; novel regulators; gene ... See more keywords
Abstract 105: Gene expression heterogeneity reveals therapeutic targets and novel regulators of metastasis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-105
Abstract: Tumor cell heterogeneity has been implicated in metastatic progression of solid tumors such as triple-negative breast cancer (TNBC), leading to resistance and recurrence. We hypothesize that genes with low cell-to-cell transcriptional variability are more effective… read more here.
Keywords: regulators metastasis; heterogeneity; novel regulators; gene expression ... See more keywords
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010013
Abstract: The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrPC may represent therapeutic targets… read more here.
Keywords: prpc; regulators prpc; rna interference; novel regulators ... See more keywords
Activin A and ALK4 Identified as Novel Regulators of Epithelial to Mesenchymal Transition (EMT) in Human Epicardial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.765007
Abstract: The epicardium, the mesothelial layer covering the heart, is a crucial cell source for cardiac development and repair. It provides cells and biochemical signals to the heart to facilitate vascularization and myocardial growth. An essential… read more here.
Keywords: mesenchymal transition; activin alk4; epicardial cells; novel regulators ... See more keywords
Circular RNAs as Novel Regulators of β-Cell Functions under Physiological and Pathological Conditions
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041503
Abstract: Circular RNAs (circRNAs) constitute a large class of non-coding RNAs characterized by a covalently closed circular structure. They originate during mRNA maturation through a modification of the splicing process and, according to the included sequences,… read more here.
Keywords: circular rnas; pathological conditions; rnas novel; regulators cell ... See more keywords
Identification of Novel Regulators of Radiosensitivity Using High-Throughput Genetic Screening
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158774
Abstract: The biological impact of ionizing radiation (IR) on humans depends not only on the physical properties and absorbed dose of radiation but also on the unique susceptibility of the exposed individual. A critical target of… read more here.
Keywords: using high; sensitivity; regulators radiosensitivity; novel regulators ... See more keywords