Identification and characterization of the novel reversible and selective cathepsin X inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11935-1
Abstract: Cathepsin X is a cysteine peptidase involved in the progression of cancer and neurodegenerative diseases. Targeting this enzyme with selective inhibitors opens a new possibility for intervention in several therapeutic areas. In this study triazole-based… read more here.
Keywords: characterization novel; reversible selective; cathepsin; novel reversible ... See more keywords
Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47672-w
Abstract: Peroxisome proliferator-activated receptor γ (PPARγ) is a major therapeutic target for the treatment of type 2 diabetes. However, the use of PPARγ-targeted drugs, such as rosiglitazone and pioglitazone, is limited owing to serious side effects… read more here.
Keywords: ppar; ppar phosphorylation; novel reversible; phosphorylation ... See more keywords
A novel reversible fluorescent probe for Cu2+ and S2− ions and imaging in living cells
Sign Up to like & getrecommendations! Published in 2022 at "Methods and Applications in Fluorescence"
DOI: 10.1088/2050-6120/ac719a
Abstract: A novel fluorescent probe TSOC (thiazole salicylaldehyde oxazole chlorinated) was synthesized based on benzothiazole conjugated olefinic bonds with salicylicaldehyde unit as fluorophore and a phenyl oxazole unit as bonding unit. The probe could reversibly detect… read more here.
Keywords: cu2; living cells; fluorescent probe; novel reversible ... See more keywords
Abstract 4871: Antitumor activity of novel reversible LSD1 inhibitor, HM97211 in preclinical models of SCLC
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4871
Abstract: Introduction: Global changes in the epigenetic landscape are known as the hallmark in cancer and the histone demethylase Lysine-specific demethylase 1 (LSD1) is one of the novel target for the therapy of various malignant diseases… read more here.
Keywords: inhibitor hm97211; lsd1 inhibitor; reversible lsd1; novel reversible ... See more keywords