Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators
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DOI: 10.1080/14756366.2022.2157825
Abstract: Abstract In this research, two novel series of dibenzo[b,f]azepines (14 candidates) were designed and synthesised based on the rigidification principle and following the reported doxorubicin’s pharmacophoric features. The anti-proliferative activity was evaluated at the NCI… read more here.
Keywords: design synthesis; synthesis novel; dibenzo; topoisomerase ... See more keywords