Two novel RNA-binding proteins identification through computational prediction and experimental validation.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.12.003
Abstract: Since RBPs play important roles in the cell, it's particularly important to find new RBPs. We performed iRIP-seq and CLIP-seq to verify two proteins, CLIP1 and DMD, predicted by RBPPred whether are RBPs or not.… read more here.
Keywords: rna binding; dmd; novel rna; irip seq ... See more keywords
A pipeline for computational design of novel RNA-like topologies
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky524
Abstract: Abstract Designing novel RNA topologies is a challenge, with important therapeutic and industrial applications. We describe a computational pipeline for design of novel RNA topologies based on our coarse-grained RNA-As-Graphs (RAG) framework. RAG represents RNA… read more here.
Keywords: pipeline; rna like; design novel; novel rna ... See more keywords
Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky873
Abstract: Abstract Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important cancer-linked protein,… read more here.
Keywords: protein; protein syndesmos; syndesmos novel; rna binding ... See more keywords
Potential Novel RNA-Targeting Agents for Effective Lipoprotein(a) Lowering: A Systematic Assessment of the Evidence from Completed and Ongoing Developmental Clinical Trials.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001429
Abstract: ABSTRACT An increase in blood lipoprotein (a) [Lp(a)] levels, mostly genetically determined, has been identified as an independent risk factor for atherosclerotic cardiovascular disease. No drug has yet been approved that markedly lowers Lp(a) and… read more here.
Keywords: potential novel; rna targeting; clinical trials; lipoprotein ... See more keywords
Novel RNA viruses within plant parasitic cyst nematodes
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0193881
Abstract: The study of invertebrate–and particularly nematode–viruses is emerging with the advancement of transcriptome sequencing. Five single-stranded RNA viruses have now been confirmed within the economically important soybean cyst nematode (SCN; Heterodera glycines). From previous research,… read more here.
Keywords: like virus; rna viruses; cyst; novel rna ... See more keywords
Novel RNA Viruses Discovered in Weeds in Rice Fields
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14112489
Abstract: Weeds often grow alongside crop plants. In addition to competing with crops for nutrients, water and space, weeds host insect vectors or act as reservoirs for viral diversity. However, little is known about viruses infecting… read more here.
Keywords: viruses discovered; stranded rna; rice; novel rna ... See more keywords