Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23210
Abstract: Our previous results showed that oligodendrocyte development is regulated by both nociceptin and its G‐protein coupled receptor, the nociceptin/orphanin FQ receptor (NOR). The present in vitro and in vivo findings show that nociceptin plays a… read more here.
Keywords: nociceptin; novel role; glutamate transporter; role ... See more keywords
The novel role of pyrvinium in cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26006
Abstract: Pyrvinium pamoate (PP) is a quinoline‐derived cyanine dye which was officially approved by FDA for its anthelmintic properties and therapeutic function against animal‐like protists such as Cryptosporidium parvum and Plasmodium falciparum in the 1950s. In… read more here.
Keywords: therapy; pyrvinium; novel role; pyrvinium cancer ... See more keywords
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2mir0917-377r
Abstract: Coinhibitory molecules, such as PD‐1, CTLA‐4, 2B4, and BTLA, are an important new family of mediators in the pathophysiology of severe bacterial and/or fungal infection, as well as the combined insults of shock and sepsis.… read more here.
Keywords: sepsis; coinhibitory receptors; immunopathology; novel role ... See more keywords
A novel role for follistatin in hypersensitivity following cystitis
Sign Up to like & getrecommendations! Published in 2017 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.22941
Abstract: Previous studies have shown that the activin‐binding protein follistatin reduces inflammation in several mouse models of colitis. To determine whether follistatin also has a beneficial effect following bladder inflammation, we induced cystitis in mice using… read more here.
Keywords: cystitis; follistatin; novel role; role follistatin ... See more keywords
A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.17-0046
Abstract: Transplantation of adult stem cells into myocardial tissue after acute myocardial infarction (AMI), has been shown to improve tissue recovery and prevent progression to ischemic cardiomyopathy. Studies suggest that the effects of mesenchymal stem cells… read more here.
Keywords: medicine; camkk1; novel role; stem ... See more keywords
A novel role for the glutamate decarboxylase system in Listeria monocytogenes; protection against oxidative stress.
Sign Up to like & getrecommendations! Published in 2020 at "Food microbiology"
DOI: 10.1016/j.fm.2019.103284
Abstract: The GAD system is widely present in several types of organisms and is known to play an important role in bacterial acid tolerance. There is only one account of this system playing a role in… read more here.
Keywords: role; system; stress resistance; novel role ... See more keywords
Novel role of forkhead box O 4 transcription factor in cancer: Bringing out the good or the bad.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2018.04.007
Abstract: Forkhead box O (FOXO) family has recently been highlighted as important transcriptional regulators associated with many diverse carcinomas. Although redundant functionality between FOXO family members with cancer is known, regulatory ability of FOXO4 for tumorigenesis… read more here.
Keywords: cancer; factor; forkhead box; novel role ... See more keywords
A novel role for CAMKIIβ in the regulation of cortical neuron migration: implications for neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0046-0
Abstract: Perturbation of CaMKIIβ expression has been associated with multiple neuropsychiatric diseases, highlighting CaMKIIβ as a gene of interest. Yet, in contrast to CaMKIIα, the specific functions of CaMKIIβ in the brain remain poorly explored. Here,… read more here.
Keywords: novel role; migration; camkii; role camkii ... See more keywords
Novel role for receptor dimerization in post-translational processing and turnover of the GRα
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32440-z
Abstract: Glucocorticoids (GCs), acting via the glucocorticoid receptor (GRα), remain the mainstay therapeutic choice for the treatment of inflammation. However, chronic GC use, aside from generating undesirable side-effects, results in GRα down-regulation, often coupled to a… read more here.
Keywords: receptor dimerization; dimerization; turnover; post translational ... See more keywords
Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance
Sign Up to like & getrecommendations! Published in 2017 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/sigtrans.2017.14
Abstract: Recently, three groups independently identified ubiquitin-specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein. In this preview, I have summarized the work of these three groups. read more here.
Keywords: nanog novel; role usp21; novel role; deubiquitylating nanog ... See more keywords
A novel role for myeloid endothelin-B receptors in hypertension
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehy881
Abstract: Abstract Aims Hypertension is common. Recent data suggest that macrophages (Mφ) contribute to, and protect from, hypertension. Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor with additional pro-inflammatory properties. We investigated the role of the… read more here.
Keywords: role myeloid; novel role; role; hypertension ... See more keywords