Synthesis of 3-oxadiazolyl/triazolyl morpholines: Novel scaffolds for drug discovery
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2016.12.052
Abstract: Abstract Synthesis of isomeric 3-oxadiazolyl/triazolyl morpholines was performed based on a common intermediate on the gram scale. The target compounds were designed as novel scaffolds for the medicinal chemistry. The key reaction was an electrochemical… read more here.
Keywords: novel scaffolds; triazolyl morpholines; synthesis; oxadiazolyl triazolyl ... See more keywords
Selenopheno[2,3-f]coumarins: novel scaffolds with antimetastatic activity against melanoma and breast cancer
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DOI: 10.1039/c9nj01682a
Abstract: The general aim of the current research is to find novel non-toxic small molecules with antimetastatic activity. read more here.
Keywords: antimetastatic activity; coumarins novel; activity; scaffolds antimetastatic ... See more keywords
Discovery of Rhodanine and Thiazolidinediones as Novel Scaffolds for EGFR Inhibition: Design, Synthesis, Analysis and CoMSIA Studies
Sign Up to like & getrecommendations! Published in 2020 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2020.1836004
Abstract: This study reports, 35 novel rhodanine, its bioisosteres thiazolidinediones and is tested for EGFR inhibition. These molecules are designed by using a pharmacophore-based superimpose approach takin... read more here.
Keywords: egfr inhibition; inhibition; thiazolidinediones novel; novel scaffolds ... See more keywords
Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2043845
Abstract: ABSTRACT Introduction The different and relevant roles of GSK-3 are of critical importance since they deal with development, metabolic homeostasis, cell polarity and fate, neuronal growth and differentiation as well as modulation of apoptotic potential.… read more here.
Keywords: products novel; kinase inhibitors; natural products; scaffolds design ... See more keywords