A novel series of substituted 1,2,3‐triazoles as cancer stem cell inhibitors: Synthesis and biological evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21723
Abstract: An alarming increase in global death toll resulting from cancer incidents, particularly due to multidrug resistance and reduced efficacy as a consequence of target mutations, has compelled us to look for novel anticancer agents. Cancer… read more here.
Keywords: cancer stem; novel series; series; cancer ... See more keywords
Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of α-(Benzoylamino)-β-substituted Acrylic Amide Derivatives of Pyrazolo[1,5-a]pyrimidine
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.3029
Abstract: A novel series of α-(benzoylamino)-β-substituted acrylic amide derivatives of pyrazolo[1,5-a]pyrimidine has been synthesized using a convergent multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI-MS, and IR analyses. Those new compounds… read more here.
Keywords: novel series; benzoylamino substituted; series benzoylamino; acrylic amide ... See more keywords
Novel series of MLa2WO7(M = Sr, Ba) microwave dielectric ceramic systems with monoclinic structures
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Materials Science: Materials in Electronics"
DOI: 10.1007/s10854-020-03633-y
Abstract: Novel series of MLa2WO7(M = Sr, Ba) ceramics were prepared via a traditional solid-state reaction method. The sintering characteristic, crystal structures, micromorphology and microwave dielectric performances of systems were systematically investigated. X-ray diffraction (XRD) and Rietveld refinement… read more here.
Keywords: microwave dielectric; series mla2wo7; novel series; blw ceramics ... See more keywords
Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.011
Abstract: Human dihydroorotate dehydrogenase (hDHODH) is a flavin-dependent enzyme essential to pyrimidine de novo biosynthesis, which serves as an attractive therapeutic target for the treatment of autoimmune disorders. A novel series of hDHODH inhibitors was developed… read more here.
Keywords: novel series; series hdhodh; hdhodh inhibitors; chemistry ... See more keywords
Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents: Their design, synthesis, and biological evaluation.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.068
Abstract: A series of novel α-terpineol derivatives were designed and synthesized through structural derivatization of the tertiary hydroxyl moiety or reduction of the double bond. Of the resulting compounds, eight compounds enhanced relaxation of airway smooth… read more here.
Keywords: anti asthmatic; novel series; terpineol derivatives; series ... See more keywords
A novel series of 1, 4-Dihydropyridine (DHP) derivatives bearing thiazolidin-4-one: From synthesis to structure
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.03.005
Abstract: Abstract A novel series of 1, 4-Dihydropyridine (DHP) thiazolidin-4-one compounds derived from dihydropyridine hydrazones Schiff bases with thioglycolic acid were synthesized through an efficient Hantzsch reaction and experimentally characterized by spectral methods using IR, 1H… read more here.
Keywords: series dihydropyridine; thiazolidin one; dihydropyridine dhp; novel series ... See more keywords
Novel series of triazole containing coumarin and isatin based hybrid molecules as acetylcholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131085
Abstract: Abstract Novel series of coumarin-triazole and isatin-triazole hybrids were rationally designed, synthesized and biologically evaluated to check their inhibitory potential against acetylcholinesterase enzyme by using in vitro Ellman's method. Most of the hybrid compounds showed… read more here.
Keywords: acetylcholinesterase inhibitors; novel series; coumarin; series triazole ... See more keywords
Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00463
Abstract: To discover a novel series of potent inhibitors of enteropeptidase, a membrane-bound serine protease localized to the duodenal brush border, 4-guanidinobenzoate derivatives were evaluated with minimal systemic exposure. The 1c docking model enabled the installation… read more here.
Keywords: novel series; enteropeptidase inhibitors; systemic exposure; guanidinobenzoate derivatives ... See more keywords
Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01620
Abstract: Herein we describe the design, synthesis, and evaluation of a novel series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and critical consideration of conformational restriction. Oxadiazine lead 47 possesses good in vitro… read more here.
Keywords: design synthesis; evaluation novel; novel series; series oxadiazine ... See more keywords
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00454
Abstract: Protein tyrosine phosphatase SHP2 is an oncogenic protein that can regulate different cytokine receptor and receptor tyrosine kinase signaling pathways. We report here the identification of a novel series of SHP2 allosteric inhibitors having an… read more here.
Keywords: novel series; discovery novel; potent shp2; shp2 allosteric ... See more keywords
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00059
Abstract: Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is the first reported nonreceptor oncogenic tyrosine phosphatase connecting multiple signal transduction cascades and exerting immunoinhibitory function through the PD-1 checkpoint receptor. As part of a drug… read more here.
Keywords: novel series; discovery novel; series; potent shp2 ... See more keywords