Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2016.11.005
Abstract: &NA; The PB1 C‐terminal domain and PB2 N‐terminal domain interaction of the influenza A polymerase, which modulates the assembly of PB1 and PB2 subunits, may serve as a valuable target for the development of novel… read more here.
Keywords: small molecule; pb1 pb2; polymerase; novel small ... See more keywords
A novel small motor measurement system based on ultrasonic bearings
Sign Up to like & getrecommendations! Published in 2021 at "Measurement"
DOI: 10.1016/j.measurement.2020.108307
Abstract: Abstract A small torque measurement system has been developed based on two novel ultrasonic levitating bearings excited by piezoelectric vibrators. The modal analysis and harmonious response analysis are conducted to investigate its characteristics and driving… read more here.
Keywords: system; small motor; novel small; measurement ... See more keywords
Novel Small-Molecule Inhibitor of NLRP3 Inflammasome Reverses Cognitive Impairment in an Alzheimer's Disease Model.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00831
Abstract: Aberrant activation of the Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays an essential role in multiple diseases, including Alzheimer's disease (AD) and psoriasis. We report a novel small-molecule inhibitor, NLRP3-inhibitory compound 7 (NIC7),… read more here.
Keywords: disease; alzheimer disease; disease model; model ... See more keywords
Novel small-molecule electron donor for solution-processed ternary exciplex with 24% external quantum efficiency in organic light-emitting diode
Sign Up to like & getrecommendations! Published in 2019 at "Materials Horizons"
DOI: 10.1039/c9mh00373h
Abstract: Efficient solution-processed exciplex OLEDs were developed by incorporating a novel small molecule electron-donor and utilizing the strategy of ternary exciplexes. read more here.
Keywords: molecule electron; electron donor; novel small; small molecule ... See more keywords
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2150183
Abstract: Abstract Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC… read more here.
Keywords: discovery novel; acid ceramidase; high throughput; ceramidase ... See more keywords
Research on function and mechanisms of a novel small molecule WG449E for hypertrophic scar
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.16028
Abstract: Hypertrophic scars are complications of severe wound healing characterized by excessive fibrosis associated with aberrant function of fibroblasts. However, no available drugs can be utilized to effectively treat these scars. The transforming growth factor β… read more here.
Keywords: novel small; function mechanisms; function; scar ... See more keywords
Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004695
Abstract: Background Inhibiting programmed cell death protein 1 (PD-1) or PD-ligand 1 (PD-L1) has shown exciting clinical outcomes in diverse human cancers. So far, only monoclonal antibodies are approved as PD-1/PD-L1 inhibitors. While significant clinical outcomes… read more here.
Keywords: small molecule; solid tumor; novel small; tumor microenvironment ... See more keywords
A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-1697
Abstract: Glioblastoma (GBM) is an aggressive and incurable primary brain tumor that causes severe neurologic, cognitive, and psychologic symptoms. Symptoms are caused and exacerbated by the infiltrative properties of GBM cells, which enable them to pervade… read more here.
Keywords: mrck; glioblastoma; invasion; small molecule ... See more keywords
Abstract 4481: Vrtx153, novel small molecule inhibitor of krasg12d
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4481
Abstract: Pancreatic cancer is an intractable malignancy and is the seventh leading cause of global cancer deaths in industrialized countries and the third most common in the USA. Despite advancement in the knowledge of potential risk… read more here.
Keywords: vrtx153 novel; krasg12d; inhibitor; novel small ... See more keywords
Novel small-molecule compound VCP979 attenuates renal fibrosis in male rats with unilateral ureteral obstruction
Sign Up to like & getrecommendations! Published in 2023 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221147569
Abstract: Renal fibrosis is a hallmark of chronic kidney disease, while efficient therapy against renal fibrosis is still lacking. In this study, we investigated the role of a novel small-molecule compound VCP979 on renal fibrosis and… read more here.
Keywords: small molecule; renal fibrosis; molecule compound; novel small ... See more keywords
Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRASG12C inhibitor, in advanced solid tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.3003
Abstract: 3003 Background: The KRASG12C mutation is found in approximately 13% of lung adenocarcinomas and 1–3% of other solid tumors, but there is no approved therapy that targets this mutation. AMG 510 is a novel small… read more here.
Keywords: 510 novel; novel small; amg 510; krasg12c ... See more keywords