Synthesis and SARs study of novel spiro-oxindoles as potent antiproliferative agents with CDK-2 inhibitory activities.
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300185
Abstract: A series of 16 novel spirooxindole analogs 8a-p were designed and constructed via cost-effective single-step multicomponent [3+2] cycloaddition reaction of azomethine ylide (AY) generated in situ from substituted isatin (6a-d) with suitable amino acids (7a-c)… read more here.
Keywords: mcf; novel spiro; synthesis sars; sars study ... See more keywords
Microwave‐assisted Domino Cyclization for the Synthesis of Novel Spiro‐benzo[a]phenazine Annulated Heterocycles Catalyzed by a Basic Ionic Liquid
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The Chinese Chemical Society"
DOI: 10.1002/jccs.201700034
Abstract: An efficient and green strategy for the improved synthesis of a biologically and pharmaceutically interesting multi-functionalized diverse novel spiro-benzo[a]phenazine annulated heterocycles was developed with the assistance of microwave irradiation. A sequential one-pot, two-step domino reaction… read more here.
Keywords: novel spiro; benzo phenazine; spiro benzo;
Synthesis and Evaluation of Novel Spiro[oxindole-isoxazolidine] Derivatives as Potent Antioxidants
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2712
Abstract: The antioxidant activity of isatin derivatives can be described with the presence of enolic hydroxyl group at the second position of the ring because of the keto-enol tautomerism between NH and CO groups of indolone… read more here.
Keywords: novel spiro; isoxazolidine derivatives; oxindole isoxazolidine; synthesis evaluation ... See more keywords
Synthesis of novel spiro[chromeno[4′,3′:3,4]pyrazolo[1,2-b]phthalazine-7,3′-indoline]-2′,6,9,14-tetraone
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-018-1506-9
Abstract: Fe3O4@Cys–SO3H magnetic nanocatalyst has been used as an effective and reusable solid acid catalyst for the one pot synthesis of novel spiro[chromeno[4′,3′:3,4]pyrazolo[1,2-b]phthalazine-7,3′-indoline]-2′,6,9,14-tetraone via a three-component reaction of phthalhydrazide, 4-hydroxycoumarin and isatin derivatives. Easy separation of… read more here.
Keywords: novel spiro; synthesis novel; chromeno pyrazolo; spiro chromeno ... See more keywords
A novel 15-spiro diterpenoid dimer from Andrographis paniculata with inhibitory potential against human carboxylesterase 2.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103680
Abstract: The phytochemical investigation of Andrographis paniculata resulted in the isolation of a novel 15-spiro diterpenoid dimer bisandrographolide G (1). Its structure was determined by 1D and 2D NMR, HRESIMS, electronic circular dichroism (ECD), and TD… read more here.
Keywords: novel spiro; diterpenoid dimer; andrographis paniculata; spiro diterpenoid ... See more keywords
A green method for the synthesis of novel spiro compounds: Enhancement of antibacterial properties of caffeic acid through electrooxidation in the presence of barbituric acid derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Electroanalytical Chemistry"
DOI: 10.1016/j.jelechem.2019.113286
Abstract: Abstract In this work, the novel Spiro cycles with high potential antibacterial activity were synthesized via a one-pot and environmentally friendly electrochemical approach, without toxic reagents and solvents. In the first, electrochemical oxidation of caffeic… read more here.
Keywords: novel spiro; presence barbituric; caffeic acid;
Diterpenoids with novel 6/5-5 spiro tricyclic skeleton from Orthosiphon wulfenioides and their NLRP3 inflammasome inhibitory activity
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00247k
Abstract: Wulfenioidins A−C (1−3) with an unprecedented 6/5−5 tricyclic skeleton featuring unusual spiro [4.4] nonane were isolated from the whole plant of Orthosiphon wulfenioides. Their structures were elucidated by X-ray diffraction,... read more here.
Keywords: novel spiro; tricyclic skeleton; orthosiphon wulfenioides; diterpenoids novel ... See more keywords