Synthesis and biological screening of some novel 6‐substituted 2‐alkylpyridazin‐3(2H)‐ones as anti‐inflammatory and analgesic agents
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900295
Abstract: Some novel derivatives of 2‐alkyl 6‐substituted pyridazin‐3(2H)‐ones were synthesized by condensation of 3,6‐dichloropyridazine with the sodium salt of benzyl cyanide, followed by hydrolysis and coupling with alkyl halides. The synthesized compounds were screened as cyclooxygenase… read more here.
Keywords: anti inflammatory; biological screening; novel substituted; substituted alkylpyridazin ... See more keywords
Novel substituted 1,8-naphthyridines: Design, synthesis, radiolabeling, and evaluation of apoptosis and topoisomerase II inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300035
Abstract: A series of seventeen 1,8-naphthyridine derivatives (5a-5q) conjugated at N1 to various substituted phenyl rings were designed and synthesized as potential topoisomerase II (Topo II) inhibitors. The antiproliferative activity of the target compounds against three… read more here.
Keywords: inhibition; apoptosis; naphthyridines design; topoisomerase ... See more keywords
Design, synthesis, and fungicidal activity of novel N-substituted piperazine-containing phenylpyridines against cucumber downy mildew.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6798
Abstract: BACKGROUND Cucumber downy mildew (CDM) is a severe plant disease and affects the yield of cucumber production worldwide. As the resistance toward conventional fungicides is emerging as a ubiquitous issue, it is urgent to discover… read more here.
Keywords: piperazine containing; downy mildew; cucumber downy; substituted piperazine ... See more keywords
Synthesis and structure of novel Si-substituted silylpropyl derivatives of 2-mercaptobenzoxazole and 2-mercaptobenzothiazole
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02532-3
Abstract: A previously unknown carbofunctional (trimethoxysilyl)propyl derivative of the 2-mercaptobenzoxazole, C6H4NOCS(CH2)3Si(OMe)3, containing a tetracoordinated silicon atom was synthesized by nucleophilic substitution of the chlorine atom in the (3-chloropropyl)-trimethoxysilane with the benzoxazol-2-ylsulfanyl group. The reaction of 2-[(trimethoxysilyl)propylsulfanyl]benzoxazole… read more here.
Keywords: substituted silylpropyl; structure novel; mercaptobenzoxazole mercaptobenzothiazole; novel substituted ... See more keywords
Novel substituted porphyrins: synthesis, characterization and photocatalytic activity of their TiO2-based composites
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inclusion Phenomena and Macrocyclic Chemistry"
DOI: 10.1007/s10847-017-0724-6
Abstract: Four novel porphyrins and their corresponding zinc complexes were synthesized and characterized spectroscopically. Effects of the spacer length of peripheral substituents of porphyrin are investigated in TiO2-porphyrins hybrid systems by photodegradation of methyl orange in… read more here.
Keywords: tio2; novel substituted; photocatalytic activity; substituted porphyrins ... See more keywords
Synthesis of novel substituted 3-(4-((1H-benzo[d]imidazol-2-ylthio)methyl)-1-phenyl-1H-pyrazol-3-yl)-2H-chromen-2-ones: various approaches
Sign Up to like & getrecommendations! Published in 2018 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-018-3397-x
Abstract: Considering benzimidazole as a privileged structure for developing probes of impressive pharmacological potentials, some new coumarin and pyrazole conjugates of benzimidazoles were synthesized with a sulphur linkage. Thus, 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde (3) was prepared starting from simple… read more here.
Keywords: synthesis novel; novel substituted; imidazol ylthio; various approaches ... See more keywords
A novel Na substituted Li3-xNaxPS4 mixed ions solid electrolyte for all solid-state lithium batteries
Sign Up to like & getrecommendations! Published in 2020 at "Applied Surface Science"
DOI: 10.1016/j.apsusc.2020.146739
Abstract: Abstract In this work, a novel Na substituted Li3-xNaxPS4 mixed-ions solid electrolyte is prepared by ball milling process. Various physio-chemical characterization techniques such as high-power X-ray diffraction, laser Raman spectroscopy, field emission scanning electron microscopy,… read more here.
Keywords: li3 xnaxps4; substituted li3; solid electrolyte; novel substituted ... See more keywords
Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111635
Abstract: The discovery of novel potent neuraminidase (NA) inhibitors remains an attractive approach for treating infectious diseases caused by influenza. In this study, we describe the design and synthesis of novel N-substituted oseltamivir derivatives for probing… read more here.
Keywords: design synthesis; oseltamivir derivatives; substituted oseltamivir; novel substituted ... See more keywords
Adsorption of palladium(II) from hydrochloric acid solutions using polymeric resins impregnated with novel N-substituted 2-(diphenylthiophosphoryl)acetamides
Sign Up to like & getrecommendations! Published in 2017 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2017.06.068
Abstract: Abstract Novel N-substituted 2-(diphenylthiophosphoryl)acetamides ligands containing pyridine and quinoline fragments, were synthesized and studied as extractants for Pd(II) ions from HCl solutions. The introduction of a pyridine and a quinoline fragments into 2-diphenylthiophosphorylacetamide molecule resulted… read more here.
Keywords: acid solutions; adsorption; novel substituted; diphenylthiophosphoryl acetamides ... See more keywords
Straightforward synthesis of novel substituted 1,3,4-thiadiazole derivatives in choline chloride-based deep eutectic solvent
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.01.057
Abstract: A one-pot, three-component route for the synthesis of novel 1,3,4-thiadiazole derivatives using a ketene S,S-acetal, a carbonyl compound and thiocarbohydrazide is described. The main advantages of this approach are high yields, short reaction times, simple… read more here.
Keywords: synthesis novel; straightforward synthesis; novel substituted; substituted thiadiazole ... See more keywords
Synthesis of novel 5-substituted isophthalates from vinamidinium salts
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151002
Abstract: Abstract Novel 5-substituted isophthalates were synthesized from the reaction of 2-substituted 1,3-bis(dimethylamino)-trimethinium salts with 1,3-bis(alkoxycarbonyl)acetone derivatives in the presence of sodium methoxide in ethanol at reflux. read more here.
Keywords: vinamidinium salts; novel substituted; synthesis novel; substituted isophthalates ... See more keywords