Efficient click reaction towards novel sulfonamide hybrids by molecular hybridization strategy as antiproliferative agents
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DOI: 10.1007/s12039-017-1415-y
Abstract: Abstract Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. The target sulfonamide hybrids were obtained in the click reaction of azide derivatives and commerciallly available alkynes. All sulfonamide hybrids were evaluated for their antiproliferative… read more here.
Keywords: click reaction; sulfonamide hybrids; molecular hybridization; novel sulfonamide ... See more keywords
Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents
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DOI: 10.3390/ijms23084241
Abstract: Toxoplasma gondii (T. gondii) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids 3a–c were wisely designed and synthesized via… read more here.
Keywords: characterization nanoformulation; sulfonamide triazole; nanoformulation novel; synthesis characterization ... See more keywords
Challenging breast cancer through novel sulfonamide-pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis.
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DOI: 10.4155/fmc-2022-0197
Abstract: Background: Among the important key modulators of the tumor microenvironment and hypoxia is a family of enzymes named carbonic anhydrases. Herein, 11 novel sulfonamide-pyridine hybrids (2-12) were designed, synthesized and biologically evaluated for their potential… read more here.
Keywords: sulfonamide pyridine; pyridine hybrids; breast; breast cancer ... See more keywords