Development of novel C2-symmetrical [5]oxahelicenoid diols
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DOI: 10.1016/j.tetlet.2021.153026
Abstract: Abstract Novel C2-symmetric [5]oxahelicenoid diols were synthesized via dehydroaromatization from the previous reported [5]oxahelicenoid dione 7 starting from 2-diazocyclohexane-1,3-dione and furan. The key dehydroaromatization reaction can be realized either by DDQ mediated or Pd/C catalyzed… read more here.
Keywords: development novel; oxahelicenoid diols; novel symmetrical; oxahelicenoid ... See more keywords
Novel Symmetrical Cage Compounds as Inhibitors of the Symmetrical MRP4-Efflux Pump for Anticancer Therapy
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DOI: 10.3390/ijms22105098
Abstract: Within the last decades cancer treatment improved by the availability of more specifically acting drugs that address molecular target structures in cancer cells. However, those target-sensitive drugs suffer from ongoing resistances resulting from mutations and… read more here.
Keywords: cancer; mrp4; novel symmetrical; efflux pump ... See more keywords