A novel synthetic sRNA promoting protein overexpression in cell-free systems.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology progress"
DOI: 10.1002/btpr.3324
Abstract: Bacterial small RNAs (sRNAs) that regulate gene expression have been engineered for uses in synthetic biology and metabolic engineering. Here, we designed a novel non-Hfq-dependent sRNA scaffold that makes use of a 20 nt antisense… read more here.
Keywords: cell free; novel synthetic; expression; srna ... See more keywords
In vitro metabolism of the novel synthetic opioid agonist cyclopropylfentanyl and subsequent confirmation in authentic human samples using liquid chromatography-high resolution mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2611
Abstract: Novel synthetic opioids (NSOs) are a class of novel psychoactive substances (NPS) that are growing in popularity and presenting a significant public health risk. Included in this class are derivatives of the highly potent analgesic,… read more here.
Keywords: high resolution; chromatography high; novel synthetic; mass ... See more keywords
The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone‐induced death, through the NGF receptor TrkA
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23170
Abstract: BNN27, a member of a chemical library of C17‐spiroepoxy derivatives of the neurosteroid DHEA, has been shown to regulate neuronal survival through its selective interaction with NGF receptors (TrkA and p75NTR), but its role on… read more here.
Keywords: cuprizone; novel synthetic; mature oligodendrocytes; ngf ... See more keywords
Novel synthetic approach to non-natural conformationally rigid spiro-linked amino acids
Sign Up to like & getrecommendations! Published in 2019 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-019-2452-0
Abstract: Abstract1-Aminospiro[2.3]hexane-1,5-dicarboxylic and 1-ammo-5-(ammomethyl)spiro[2.3]hexane-1-carboxylic acids, which are the conformationally rigid analogues of glutamic acid and lysine, respectively, were synthesized from 3-methylidenecyclobutanecarbonitrile. The synthetic route includes a catalytic [1+2]-cycloaddition of ethyl 2-diazo-2-nitroacetate to a double bond of… read more here.
Keywords: novel synthetic; non natural; spiro; approach non ... See more keywords
5-Phenyl- and 5,10-diphenyltetrabenzoporphyrins: Novel synthetic approach, physicochemical study with an emphasis on NMR spectroscopy, and identification of benzylated derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2019.108130
Abstract: Abstract Novel synthetic approach to low-symmetry meso-phenylsubstituted tetrabenzoporphyrins (TPBs) by Zn(OAc)2 templated assembly of phthalonitrile in the presence of benzyltriphenylphosphonium chloride has been proposed affording two main products: 5-phenyl-21H,23H-TBP (1) and 5,10-diphenyl-21H,23H-TBP (2) with higher… read more here.
Keywords: novel synthetic; synthetic approach; physicochemical study; spectroscopy ... See more keywords
Novel synthetic clays for the adsorption of surfactants from aqueous media.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of environmental management"
DOI: 10.1016/j.jenvman.2017.10.053
Abstract: The aim of this work was to assess for the first time the use of two high-charge swelling micas (Na-Mica-4 and C18-Mica-4) for the removal of four linear alkylbenzene sulfonates (LAS) from aqueous samples. To… read more here.
Keywords: mica; adsorption; novel synthetic; removal rates ... See more keywords
Pharmacodynamics and pharmacokinetics of the novel synthetic opioid, U-47700, in male rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108195
Abstract: Novel synthetic opioids are appearing in recreational drug markets worldwide as adulterants in heroin or ingredients in counterfeit analgesic medications. 3,4-Dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) is an example of a non-fentanyl synthetic opioid linked to overdose deaths. Here,… read more here.
Keywords: opioid 47700; novel synthetic; pharmacokinetics novel; pharmacodynamics pharmacokinetics ... See more keywords
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108475
Abstract: The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present study was to… read more here.
Keywords: synthetic cathinones; role amino; amino terminal; novel synthetic ... See more keywords
Polyamidoaminoepichlorohydrin resin a novel synthetic anti-corrosive water soluble polymer for mild steel
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Organic Coatings"
DOI: 10.1016/j.porgcoat.2017.04.034
Abstract: Abstract A novel polyamidoaminoepichlorohydrin resin was prepared and analyzed using spectroscopy techniques and its anti-corrosion properties were studied and observed. Inhibition efficiency was calculated by impedance spectroscopy, loss in weight and potentiodynamic polarization. Authors inferred… read more here.
Keywords: anti corrosive; novel synthetic; resin novel; spectroscopy ... See more keywords
A novel synthetic method of 2,4-disubstituted oxazoles using carboxylic acid-derived Bu2Sn[OC(O)R]2
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.151983
Abstract: Abstract A novel synthetic method for the preparation of 2,4-disubstituted oxazoles was developed, entailing the reaction of dibutyltin diacylates Bu2Sn[OC(O)R]2 with 1-substituted acetylenes and TMSN3 to afford a range of 2,4-disubstituted oxazoles in good yields. read more here.
Keywords: disubstituted oxazoles; novel synthetic; oxazoles using; method disubstituted ... See more keywords
Novel Synthetic Polymer-Based 3D Contraction Assay: A Versatile Preclinical Research Platform for Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c02549
Abstract: The driving factors causing fibrosis and scar formation include fibroblast differentiation into myofibroblasts and hampered myofibroblast apoptosis, which ultimately results in collagen accumulation and tissue contraction. Currently, only very few drugs are available for fibrosis… read more here.
Keywords: pic rgd; platform; contraction; novel synthetic ... See more keywords