Methionine329 in human serum albumin: A novel target for alkylation by sulfur mustard.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2548
Abstract: Exposure to the vesicant sulfur mustard (SM) may lead to erythema and blistering. Toxicity of SM is hypothesized due to the alkylation of DNA bases and nucleophilic amino acid side chains in proteins (adducts) by… read more here.
Keywords: sulfur mustard; serum; human serum; novel target ... See more keywords
Monocarboxylate transporter 1 is a novel target for breast cancer stem like‐cell inhibition by diallyl trisulfide
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23415
Abstract: Diallyl trisulfide (DATS) is a promising small molecule phytochemical that exhibits in vitro and in vivo activity in multiple preclinical solid tumor models including breast cancer, but the underlying mechanism is not fully understood. We… read more here.
Keywords: inhibition; breast; mct1; breast cancer ... See more keywords
MUC16 as a novel target for cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1498845
Abstract: ABSTRACT Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe the role of MUC16 under normal physiological conditions… read more here.
Keywords: muc16 novel; muc16; target cancer; novel target ... See more keywords
Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive Sciences"
DOI: 10.1177/1933719118757683
Abstract: Background: Spontaneous preterm labor leading to preterm birth is a significant obstetric problem leading to neonatal morbidity and mortality. Current tocolytics are not completely effective and novel targets may afford a therapeutic benefit. Objective: To… read more here.
Keywords: ano family; target tocolysis; novel target; pregnant human ... See more keywords
AMPK: a novel target for treating hepatic fibrosis.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19376
Abstract: Fibrosis is a common process of excessive extracellular matrix (ECM) accumulation following inflammatory injury. Fibrosis is involved in the pathogenesis of almost all liver diseases for which there is no effective treatment. 5'-AMP-activated protein kinase… read more here.
Keywords: fibrosis; ampk novel; novel target; hepatic fibrosis ... See more keywords
Bcs1, a novel target for fungicide
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1146753
Abstract: The mitochondrial respiratory chain has long been a primary target for the development of fungicides for its indispensable role in various cellular functions including energy metabolism. Over the years, a wide range of natural and… read more here.
Keywords: respiratory chain; bcs1; novel target; bcs1 novel ... See more keywords
Exploring novel targets of sitagliptin for type 2 diabetes mellitus: Network pharmacology, molecular docking, molecular dynamics simulation, and SPR approaches
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1096655
Abstract: Background Diabetes has become a serious global public health problem. With the increasing prevalence of type 2 diabetes mellitus (T2DM), the incidence of complications of T2DM is also on the rise. Sitagliptin, as a targeted… read more here.
Keywords: sitagliptin; pharmacology; novel target; diabetes mellitus ... See more keywords
Corrigendum: Sphingosine 1-Phosphate: A Novel Target for Lung Disorders
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01628
Abstract: [This corrects the article DOI: 10.3389/fimmu.2017.00296.]. read more here.
Keywords: lung disorders; corrigendum sphingosine; novel target; phosphate novel ... See more keywords
αDβ2 as a novel target of experimental polymicrobial sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1059996
Abstract: Since sepsis was defined three decades ago, it has been a target of intensive study. However, there is no specific sepsis treatment available, with its high mortality and morbidity. αDβ2 (CD11d/CD18) is one of the… read more here.
Keywords: sepsis; target experimental; experimental polymicrobial; polymicrobial sepsis ... See more keywords
The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.01627
Abstract: Tuberculosis (TB) poses an enduring threat to global health. Consistently ranked among the top 10 causes of death worldwide since 2000, TB has now exceeded HIV-AIDS in terms of deaths inflicted by a single infectious… read more here.
Keywords: target space; mycobacterial membrane; novel target; membrane novel ... See more keywords
Non-homologous End Joining-Mediated Insertional Mutagenesis Reveals a Novel Target for Enhancing Fatty Alcohols Production in Yarrowia lipolytica
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.898884
Abstract: Non-homologous end joining (NHEJ)-mediated integration is effective in generating random mutagenesis to identify beneficial gene targets in the whole genome, which can significantly promote the performance of the strains. Here, a novel target leading to… read more here.
Keywords: homologous end; fatty alcohols; non homologous; novel target ... See more keywords