Methionine329 in human serum albumin: A novel target for alkylation by sulfur mustard.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2548
Abstract: Exposure to the vesicant sulfur mustard (SM) may lead to erythema and blistering. Toxicity of SM is hypothesized due to the alkylation of DNA bases and nucleophilic amino acid side chains in proteins (adducts) by… read more here.
Keywords: sulfur mustard; serum; human serum; novel target ... See more keywords
Monocarboxylate transporter 1 is a novel target for breast cancer stem like‐cell inhibition by diallyl trisulfide
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23415
Abstract: Diallyl trisulfide (DATS) is a promising small molecule phytochemical that exhibits in vitro and in vivo activity in multiple preclinical solid tumor models including breast cancer, but the underlying mechanism is not fully understood. We… read more here.
Keywords: inhibition; breast; mct1; breast cancer ... See more keywords
CCAT2 role in gastrointestinal cancer progression and metastasis: a novel target for therapeutic strategies
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-025-01730-y
Abstract: Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNAs that have over 200 nucleotides. Various studies have shown that aberrant expression of lncRNAs can lead to the development of different tumors. Furthermore, recent findings… read more here.
Keywords: cancer; ccat2 role; progression; novel target ... See more keywords
MUC16 as a novel target for cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1498845
Abstract: ABSTRACT Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe the role of MUC16 under normal physiological conditions… read more here.
Keywords: muc16 novel; muc16; target cancer; novel target ... See more keywords
Identification of Potential Novel Target Therapy for Familial Hypertension: In Silico-based Multi-level Bioinformatic Analysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0001118628.68303.cc
Abstract: bias. All three studies had moderate risks in participant selection due to lack of standardized start time. Chang et al and Doege et al reported inability to control for at least one major confounder. Conclusion:… read more here.
Keywords: therapy familial; potential novel; target therapy; novel target ... See more keywords
Abstract 5953: DUSP6 is a novel target in neuroendocrine tumors
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5953
Abstract: Background: Neuroendocrine tumors (NETs) are rare malignancies derived from enterochromaffin cells of the diffuse neuroendocrine system and most frequently observed in the gastrointestinal tract and bronchopulmonary system. Surgery is the major treatment for localized NETs.… read more here.
Keywords: dusp6; target neuroendocrine; dusp6 novel; novel target ... See more keywords
BTN2A1: A Novel Target to Boost Tumor Killing Capacity of Human γδ T Cells.
Sign Up to like & getrecommendations! Published in 2024 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-24-0925
Abstract: γδ T cells have recently raised great interest as effector cells in cancer immunotherapy because of their HLA-independent mode of action and their broad tumor reactivity. To translate the application of γδ T cells into… read more here.
Keywords: tumor killing; btn2a1 novel; target boost; tumor ... See more keywords
Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive Sciences"
DOI: 10.1177/1933719118757683
Abstract: Background: Spontaneous preterm labor leading to preterm birth is a significant obstetric problem leading to neonatal morbidity and mortality. Current tocolytics are not completely effective and novel targets may afford a therapeutic benefit. Objective: To… read more here.
Keywords: ano family; target tocolysis; novel target; pregnant human ... See more keywords
AMPK: a novel target for treating hepatic fibrosis.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19376
Abstract: Fibrosis is a common process of excessive extracellular matrix (ECM) accumulation following inflammatory injury. Fibrosis is involved in the pathogenesis of almost all liver diseases for which there is no effective treatment. 5'-AMP-activated protein kinase… read more here.
Keywords: fibrosis; ampk novel; novel target; hepatic fibrosis ... See more keywords
Bcs1, a novel target for fungicide
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1146753
Abstract: The mitochondrial respiratory chain has long been a primary target for the development of fungicides for its indispensable role in various cellular functions including energy metabolism. Over the years, a wide range of natural and… read more here.
Keywords: respiratory chain; bcs1; novel target; bcs1 novel ... See more keywords
Exploring novel targets of sitagliptin for type 2 diabetes mellitus: Network pharmacology, molecular docking, molecular dynamics simulation, and SPR approaches
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1096655
Abstract: Background Diabetes has become a serious global public health problem. With the increasing prevalence of type 2 diabetes mellitus (T2DM), the incidence of complications of T2DM is also on the rise. Sitagliptin, as a targeted… read more here.
Keywords: sitagliptin; pharmacology; novel target; diabetes mellitus ... See more keywords