Novel targeted C3 inhibitor pegcetacoplan for paroxysmal nocturnal hemoglobinuria
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-022-00830-3
Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening acquired blood disease characterized by chronic complement-mediated hemolysis and thrombosis. On May 14, 2021, the US FDA approved a new targeted C3 therapy Empaveli (pegcetacoplan), once called… read more here.
Keywords: paroxysmal nocturnal; nocturnal hemoglobinuria; novel targeted; pegcetacoplan ... See more keywords
Novel Targeted Therapeutics in Acute Myeloid Leukemia: an Embarrassment of Riches
Sign Up to like & getrecommendations! Published in 2021 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-021-00621-9
Abstract: Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow that has a poor prognosis with traditional cytotoxic chemotherapy, especially in elderly patients. In recent years, small molecule inhibitors targeting AML-associated IDH1, IDH2,… read more here.
Keywords: myeloid leukemia; targeted therapeutics; novel agents; novel targeted ... See more keywords
Novel targeted therapies for the management of liver fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Emerging Drugs"
DOI: 10.1080/14728214.2020.1735350
Abstract: ABSTRACT Introduction: Prolonged liver injury results in tissue damage and replacement by extracellular matrix and fibrosis. Cirrhosis represents a leading cause of mortality worldwide and imposes a major financial burden on health-care systems. Fortunately, fibrogenesis… read more here.
Keywords: fibrotic agents; anti fibrotic; fibrosis; novel targeted ... See more keywords
SCIMP: A Novel Targeted Gene for Postmenopausal Osteoporosis Progression
Sign Up to like & getrecommendations! Published in 2023 at "Orthopaedic Surgery"
DOI: 10.1111/os.13715
Abstract: The literature suggests that not all postmenopausal women suffer from osteoporosis, and the occurrence of postmenopausal osteoporosis is closely related to the genetic susceptibility of genes in the population and the cellular pathways of related… read more here.
Keywords: scimp novel; osteoporosis; targeted gene; novel targeted ... See more keywords
Combined MEK and PI3K/p110b inhibition as a novel targeted therapy for malignant mesothelioma displaying sarcomatoid features.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-1633
Abstract: Among malignant mesotheliomas (MM) the sarcomatoid subtype is associated with higher chemoresistance and worst survival. Due to its low incidence, there has been little progress in the knowledge of the molecular mechanisms associated with sarcomatoid… read more here.
Keywords: pi3k; combined mek; targeted therapy; inhibition ... See more keywords
Abstract 3307: A novel targeted RNA sequencing approach for identification of aggressive prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3307
Abstract: Introduction: Prostate cancer (PC) is a highly heterogeneous disease and can be either aggressive, requiring immediate treatment, or remain slow growing and even without treatment present no significant symptoms throughout the man’s life. Currently, there… read more here.
Keywords: prostate cancer; targeted rna; risk; novel targeted ... See more keywords
Nanobubbles: A Novel Targeted Drug Delivery System
Sign Up to like & getrecommendations! Published in 2022 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-97902022e19604
Abstract: Nanobubbles are nanometer size bubbles having different constituents of varying physicochemical characteristic for the inner core and outer shell. Nanobubbles are mainly fabricated to improve the stability, bioavailability and improve the biodistribution of the delivered… read more here.
Keywords: targeted drug; nanobubbles novel; drug delivery; novel targeted ... See more keywords
Novel targeted drugs for follicular and marginal zone lymphoma: a comprehensive review
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1170394
Abstract: Although mostly incurable, indolent non-Hodgkin lymphomas (iNHL) are chronic diseases with a median overall survival approaching 20 years. In recent years, important advances in the knowledge of the biology of these lymphomas have led to… read more here.
Keywords: marginal zone; zone lymphoma; follicular marginal; novel targeted ... See more keywords
Novel Targeted Therapeutic Strategies for Ewing Sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14081988
Abstract: Simple Summary Ewing sarcoma is an uncommon cancer that arises in mesenchymal tissues and represents the second most widespread malignant bone neoplasm after osteosarcoma in children. Therapy has increased the 5-year survival rate in the… read more here.
Keywords: therapeutic strategies; sarcoma; ewing sarcoma; novel targeted ... See more keywords
Update on Novel Targeted Therapy for Pleural Organization and Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031587
Abstract: Pleural injury and subsequent loculation is characterized by acute injury, sustained inflammation and, when severe, pathologic tissue reorganization. While fibrin deposition is a normal part of the injury response, disordered fibrin turnover can promote pleural… read more here.
Keywords: update novel; pleural mesothelial; injury; mesothelial cells ... See more keywords
Development of a Novel Targeted Metabolomic LC-QqQ-MS Method in Allergic Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12070592
Abstract: The transition from mild to severe allergic phenotypes is still poorly understood and there is an urgent need of incorporating new therapies, accompanied by personalized diagnosis approaches. This work presents the development of a novel… read more here.
Keywords: methodology; development novel; allergic inflammation; targeted metabolomic ... See more keywords