Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-60733-7_1
Abstract: Genome stability is maintained by a number of elegant mechanisms, which sense and repair damaged DNA. Germline defects that compromise genomic integrity result in cancer predisposition, exemplified by rare syndromes caused by mutations in certain… read more here.
Keywords: medicine; dna repair; approaches identifying; novel targets ... See more keywords
Recent advances, novel targets and treatments for cholelithiasis; a narrative review.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174376
Abstract: Cholelithiasis is a common and frequent condition all over the world with a high prevalence rate in western countries. Individuals with cholesterol gallstone disease experience intense gastrointestinal symptoms and have a high risk of developing… read more here.
Keywords: cholesterol gallstones; advances novel; cholesterol; novel targets ... See more keywords
MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad001
Abstract: Adaptive introgression (AI) facilitates local adaptation in a wide range of species. Many state-of-the-art methods detect AI with ad-hoc approaches that identify summary statistic outliers or intersect scans for positive selection with scans for introgressed… read more here.
Keywords: reveals novel; introgression; maladapt reveals; adaptive introgression ... See more keywords
Gastroduodenal injury and repair: novel targets for therapeutic intervention
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Gastroenterology"
DOI: 10.1097/mog.0000000000000883
Abstract: Purpose of review Although the mucosal barrier serves as a primary interface between the environment and host, little is understood about the repair of acute, superficial lesions or deeper, persistent lesions that if not healed,… read more here.
Keywords: gastroduodenal injury; novel targets; repair novel; injury ... See more keywords
Beyond monoamines: I. Novel targets and radiotracers for Positron emission tomography imaging in psychiatric disorders
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15615
Abstract: With the emergence of positron emission tomography (PET) in the late 1970s, psychiatry had access to a tool capable of non‐invasive assessment of human brain function. Early applications in psychiatry focused on identifying characteristic brain… read more here.
Keywords: psychiatric disorders; positron emission; development; novel targets ... See more keywords
Abstract LB062: Identifying novel targets for CAR-T therapies from single cell RNA-sequencing data
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb062
Abstract: Chimeric antigen receptor T (CAR-T) cell therapies have revolutionized cancer treatment. While CAR-T has yielded tremendous clinical success for patients with liquid tumors, its potential remains to be unleashed against solid tumors. One key challenge… read more here.
Keywords: cell; identifying novel; novel targets; car ... See more keywords
Novel Targets in Pancreatic Cancer Therapy - Current Status and Ongoing Translational Efforts
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Research and Treatment"
DOI: 10.1159/000493437
Abstract: Pancreatic ductal adenocarcinoma (PDAC, pancreatic cancer) carries one of the poorest overall prognoses of all human malignancies known to date. Despite the introduction of novel therapeutic regimens, the outcome has not markedly improved over the… read more here.
Keywords: therapy current; targets pancreatic; pancreatic cancer; novel targets ... See more keywords
Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0673-3
Abstract: A major advance in antimalarial drug discovery has been the shift towards cell-based phenotypic screening, with notable progress in the screening of compounds against the asexual blood stage, liver stage, and gametocytes. A primary method… read more here.
Keywords: omics based; identify novel; drug; methods identify ... See more keywords
A Recent Achievement In the Discovery and Development of Novel Targets for the Treatment of Type-2 Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Experimental Pharmacology"
DOI: 10.2147/jep.s226113
Abstract: Abstract Type 2 diabetes (T2DM) is a chronic metabolic disorder. Impaired insulin secretion, enhanced hepatic glucose production, and suppressed peripheral glucose use are the main defects responsible for developing the disease. Besides, the pathophysiology of… read more here.
Keywords: novel targets; discovery; development; treatment ... See more keywords
Novel Targets for Therapeutic Intervention in Inflammatory Bowel Disease: Research Drives Clinic.
Sign Up to like & getrecommendations! Published in 2019 at "Current pharmaceutical design"
DOI: 10.2174/138161282501190514105602
Abstract: Editorial Novel Targets for Therapeutic Intervention in Inflammatory Bowel Disease: Research Drives Clinic Over the past years, Inflammatory Bowel Disease (IBD), has become one of the most innovative chapters in Gastroenterology. Not only because its… read more here.
Keywords: bowel disease; inflammatory bowel; disease; novel targets ... See more keywords
Collocating novel targets for Tuberculosis (TB) Drug Discovery.
Sign Up to like & getrecommendations! Published in 2020 at "Current drug discovery technologies"
DOI: 10.2174/1570163817666200121143036
Abstract: BACKGROUND Mycobacterium tuberculosis, being a resistive species is an incessant threat to the world population for the treatment of Tuberculosis (TB). An advanced genetic or a molecular level approach is mandatory for both diagnosis and… read more here.
Keywords: collocating novel; tuberculosis drug; drug; novel targets ... See more keywords