Myoepithelial Carcinoma Ex-Pleomorphic Adenoma: A Rare Pathology Misdiagnosed as Pleomorphic Adenoma; With a Novel TERT Promoter Mutation and High PD-L1 Expression
Sign Up to like & getrecommendations! Published in 2021 at "Head and Neck Pathology"
DOI: 10.1007/s12105-021-01346-0
Abstract: Myoepithelial carcinoma (MECA) is a rare salivary gland (SG) neoplasm (0.1–0.45% of all SG tumors) that often presents with bland cytomorphology and can be misclassified as cellular pleomorphic adenoma (PA) or myoepithelioma. This is particularly… read more here.
Keywords: myoepithelial carcinoma; novel tert; pathology; pleomorphic adenoma ... See more keywords
Abstract 3117: Eribulin is a novel TERT-targeting inhibitor that penetrates into intracerebrally grown glioblastomas and suppresses their growth in mice
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3117
Abstract: [Introduction] No effective molecular targeting therapy has been clinically developed for patients with glioblastoma (GBM) despite of intense genome analysis. Approximately 60-80% of GBM harbor mutations in the promoter region of TERT that leads to… read more here.
Keywords: novel tert; cell; mice; tert ... See more keywords
A Novel N-Tert-Butyl Derivatives of Pseudothiohydantoin as Potential Target in Anti-Cancer Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26092612
Abstract: Tumors are currently more and more common all over the world; hence, attempts are being made to explain the biochemical processes underlying their development. The search for new therapeutic pathways, with particular emphasis on enzymatic… read more here.
Keywords: anti cancer; tert butyl; activity; novel tert ... See more keywords