Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5243
Abstract: Choriocarcinoma is a rare and aggressive gynecological malignancy. The standard treatment is systemic chemotherapy as choriocarcinoma exhibits high chemosensitivity. However, refractory choriocarcinoma exhibits chemoresistance; thus, the prognosis remains very poor. This study aimed to identify… read more here.
Keywords: choriocarcinoma; drug library; novel therapeutic; library screening ... See more keywords
MST4 as a novel therapeutic target for autophagy and radiosensitivity in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2682
Abstract: Mammalian ste20‐like kinase 4 (MST4) and autophagy have been implicated in ailments such as inflammatory and cancers. read more here.
Keywords: therapeutic target; mst4 novel; novel therapeutic; autophagy radiosensitivity ... See more keywords
Junctophilins emerge as novel therapeutic targets
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28405
Abstract: Junctophilins (JPs) emerge to play key role in human pathophysiology. This family includes four subtypes (JP1–4), which are differentially detected in excitable cells. Previous work demonstrated the knockout of JPs that seriously damage physiological functions… read more here.
Keywords: therapeutic targets; emerge novel; disease; jps ... See more keywords
Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism
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DOI: 10.1002/jimd.12540
Abstract: Patients with urea cycle disorders intermittently develop episodes of decompensation with hyperammonemia. Although such an episode is often associated with starvation and catabolism, its molecular basis is not fully understood. First, we attempted to elucidate… read more here.
Keywords: moving towards; novel therapeutic; therapeutic strategy; starvation ... See more keywords
Allogeneic mesenchymal stromal cells: Novel therapeutic option for mutated FLNA‐associated respiratory failure in the pediatric setting
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.24497
Abstract: Mesenchymal stromal cell (MSC)‐mediated therapeutic effects have been observed in the treatment of lung diseases. For the first time, this treatment was used as rescue therapy in a pediatric patient with a life‐threatening respiratory syndrome… read more here.
Keywords: mesenchymal stromal; stromal cells; therapeutic option; cells novel ... See more keywords
Novel therapeutic targets in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2019 at "Prescriber"
DOI: 10.1002/psb.1739
Abstract: SMAD7 antisense oligonucleotides and sphingosine‐1‐phosphate receptor modulators are new oral agents that are being investigated as potential treatments for inflammatory bowel disease (Crohn's disease and ulcerative colitis). This article reports on some of the clinical… read more here.
Keywords: bowel disease; inflammatory bowel; targets inflammatory; therapeutic targets ... See more keywords
Novel Therapeutic Platform of Micelles and Nanogels from Dopa-Functionalized Triblock Copolymers.
Sign Up to like & getrecommendations! Published in 2021 at "Small"
DOI: 10.1002/smll.202007305
Abstract: Multi-drug delivery systems constructed from a basic polymeric scaffold, and which have the ability to target a variety of biomedical applications, can streamline the development of nanomedicine to provide both environmental and economical relief. Herein,… read more here.
Keywords: platform micelles; micelles nanogels; triblock copolymers; novel therapeutic ... See more keywords
Genomic Strategies Toward Identification of Novel Therapeutic Targets.
Sign Up to like & getrecommendations! Published in 2020 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2020_360
Abstract: Coronary artery disease, myocardial infarction, and secondary damages of the myocardium in the form of ischemic heart disease remain major causes of death in Western countries. Beyond traditional risk factors such as smoking, hypertension, dyslipidemia,… read more here.
Keywords: genomic strategies; therapeutic targets; toward identification; identification novel ... See more keywords
Nectin-4: a Novel Therapeutic Target for Skin Cancers
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DOI: 10.1007/s11864-022-00940-w
Abstract: Nectin-4 is a tumor-associated antigen that is highly expressed on various cancer cells, and it has been further proposed to have roles in tumor development and propagation ranging from cellular proliferation to motility and invasion.… read more here.
Keywords: nectin; enfortumab vedotin; novel therapeutic; target ... See more keywords
Epigenetics of Indolent Lymphoma and How It Drives Novel Therapeutic Approaches—Focus on EZH2-Targeted Drugs
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DOI: 10.1007/s11912-021-01076-0
Abstract: Purpose of Review Epigenetic modifier gene mutations are common in patients with follicular lymphoma. Here we review the pathogenesis of these mutations and how they are targeted by epigenetic drugs including EZH2 inhibitors in both… read more here.
Keywords: lymphoma; indolent lymphoma; lymphoma drives; drives novel ... See more keywords
Novel Therapeutic Options in Treatment of Idiopathic Inflammatory Myopathies
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DOI: 10.1007/s11940-018-0521-6
Abstract: Purpose of reviewThe purpose of this review is to update the audience on the recent progress in the treatment of idiopathic inflammatory myopathies, highlighting a myriad of treatment trials aimed at slowing down progression of… read more here.
Keywords: therapeutic options; inflammatory myopathies; idiopathic inflammatory; treatment ... See more keywords