Repurposing approved drugs on the pathway to novel therapies
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21627
Abstract: The time and cost of developing new drugs have led many groups to limit their search for therapeutics to compounds that have previously been approved for human use. Many “repurposed” drugs, such as derivatives of… read more here.
Keywords: pathway novel; drugs pathway; approved drugs; repurposing approved ... See more keywords
Novel therapies for treatment of resistant and refractory nontuberculous mycobacterial infections in patients with cystic fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.24939
Abstract: Respiratory infections caused by non‐tuberculous mycobacteria (NTM) are a major cause of morbidity for patients living with cystic fibrosis (CF), as NTM pulmonary disease (NTM‐PD) is challenging to both diagnose and eradicate. Despite the lengthy… read more here.
Keywords: cystic fibrosis; treatment resistant; fibrosis; novel therapies ... See more keywords
Novel Therapies for Acute Myeloid Leukemia: Are We Finally Breaking the Deadlock?
Sign Up to like & getrecommendations! Published in 2017 at "Targeted Oncology"
DOI: 10.1007/s11523-017-0503-8
Abstract: Acute myeloid leukemia (AML) is one of the best studied malignancies, and significant progress has been made in understanding the clinical implications of its disease biology. Unfortunately, drug development has not kept pace, as the… read more here.
Keywords: myeloid leukemia; acute myeloid; therapy; therapies acute ... See more keywords
Chronic Lymphocytic Leukemia: Chemotherapy Free and Other Novel Therapies Including CAR T
Sign Up to like & getrecommendations! Published in 2022 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-022-00953-5
Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Most individuals diagnosed with CLL will not need treatment immediately but over time the clonal B cells infiltrate the bone marrow, lymph nodes, liver,… read more here.
Keywords: leukemia; novel therapies; chronic lymphocytic; treatment ... See more keywords
Novel Therapies for Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-020-01042-6
Abstract: Purpose of Review Glioblastoma (GBM) is the most common malignant primary brain tumor, and the available treatment options are limited. This article reviews the recent preclinical and clinical investigations that seek to expand the repertoire… read more here.
Keywords: therapies glioblastoma; novel therapies;
Novel Therapies in Light Chain Amyloidosis
Sign Up to like & getrecommendations! Published in 2018 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2017.11.017
Abstract: Light chain (AL) amyloidosis is the most common form of amyloidosis involving the kidney. It is characterized by albuminuria, progressing to overt nephrotic syndrome and eventually end-stage renal failure if diagnosed late or ineffectively treated,… read more here.
Keywords: risk; chain amyloidosis; amyloidosis; light chain ... See more keywords
Hope on the horizon: promising novel therapies for necrotizing enterocolitis
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Research"
DOI: 10.1038/s41390-020-1077-1
Abstract: Necrotizing enterocolitis (NEC) remains among the most common and devastating diseases in neonates. Despite advances in neonatal clinical care, specific treatment strategies and diagnostic modalities remain lacking. As a result, morbidity and mortality remain high.… read more here.
Keywords: horizon promising; hope horizon; necrotizing enterocolitis; novel therapies ... See more keywords
Novel therapies in the treatment of noninfectious uveitis
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Ophthalmology"
DOI: 10.1080/17469899.2018.1477590
Abstract: ABSTRACT Introduction: Uveitis is a major cause of vision loss worldwide, and noninfectious uveitis (NIU) constitutes the majority of uveitis cases in the developed world. While corticosteroids were long the mainstays of uveitis therapy, there… read more here.
Keywords: treatment noninfectious; ophthalmology; noninfectious uveitis; uveitis ... See more keywords
Novel therapies for AML: a round-up for clinicians
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2020.1850255
Abstract: ABSTRACT Introduction: Acute myeloid leukemia (AML) is a deadly disease associated with poor outcomes. For over four decades, therapeutic options for AML were limited to high dose cytotoxic chemotherapy. Scientific breakthroughs have not only enhanced… read more here.
Keywords: aml round; therapies aml; round clinicians; pharmacology ... See more keywords
Novel therapies for treatment of antibody-mediated rejection of the kidney
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000001037
Abstract: Purpose of review We aim to discuss current literature on novel therapies for antibody-mediated rejection (AMR) in kidney transplantation with a focus on chronic AMR. Recent findings IL-6/IL-6 receptor blockers appear promising in the treatment… read more here.
Keywords: novel therapies; antibody mediated; mediated rejection; treatment ... See more keywords
Novel therapies for advanced urologic cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Urology"
DOI: 10.1097/mou.0000000000000775
Abstract: PURPOSE OF REVIEW Systemic treatment of advanced urogenital malignancies has changed significantly in recent years and it will continue to change rapidly in upcoming years. It is the scope of this review article to providing… read more here.
Keywords: advanced urologic; urologic cancers; therapy; therapies advanced ... See more keywords