Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine‐2,4‐dione derivatives as VEGFR‐2 inhibitors
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DOI: 10.1002/ardp.202000491
Abstract: The anticancer activity of novel thiazolidine‐2,4‐diones was evaluated against HepG2, HCT‐116, and MCF‐7 cells. Among the tested cancer cell lines, HCT‐116 was the most sensitive one to the cytotoxic effect of the new derivatives. In… read more here.
Keywords: hct 116; vegfr inhibitors; admet profile; anticancer ... See more keywords
Novel thiazolidine derivatives as potent selective pro-apoptotic agents.
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DOI: 10.1016/j.bioorg.2021.105143
Abstract: A series of 2-arylthiazolidine-4-carboxylic acid amide derivatives were synthesized and their cytotoxic activity against three cancer cell lines (PC-3, SKOV3 and MDA-MB231) was evaluated. Various structural modifications were tried including modifications of the length of… read more here.
Keywords: pro apoptotic; expression; cancer cells; cancer ... See more keywords
Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives.
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DOI: 10.1039/c7md00173h
Abstract: A series of novel thiazolidine-2,4-dione or rhodanine derivatives (5a-5k, 6a-6k) were synthesized and evaluated for their α-glucosidase inhibitory activity. The majority of compounds exhibited potent inhibitory activity in the range of 5.44 ± 0.13 to… read more here.
Keywords: dione rhodanine; rhodanine; thiazolidine dione; molecular docking ... See more keywords