Novel Thiazolidinedione and Rhodanine Derivatives Regulate Glucose Metabolism, Improve Insulin Sensitivity, and Activate the Peroxisome Proliferator-Activated γ Receptor
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DOI: 10.1021/acsomega.3c07149
Abstract: Sixteen novel thiazolidinedione (TZD) and rhodanine (RD) derivatives were designed and synthesized by introducing a pyrimidine moiety at different sites of pioglitazone’s structure. The effects of synthesized compounds on regulating glucose metabolism, improving insulin sensitivity,… read more here.
Keywords: glucose metabolism; rhodanine derivatives; novel thiazolidinedione; sensitivity ... See more keywords
Discovery of Novel Thiazolidinedione-Derivatives with Multi-Modal Antidiabetic Activities In Vitro and In Silico
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DOI: 10.3390/ijms24033024
Abstract: Diabetes mellitus (DM) and related complications continue to exert a significant burden on health care systems globally. Although conventional pharmacological therapies are beneficial in the management of this metabolic condition, it is still necessary to… read more here.
Keywords: inhibition; novel thiazolidinedione; inhibition assay; activity ... See more keywords