LAUSR

Novel TMEM173 Mutation and the Role of Disease Modifying Alleles

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1 Published in 2019 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2019.02770

Abstract: Upon binding to pathogen or self-derived cytosolic nucleic acids cyclic GMP-AMP synthase (cGAS) triggers the production of cGAMP that further activates transmembrane protein STING. Upon activation STING translocates from ER via Golgi to vesicles. Monogenic… read more here.

Keywords: mutation role; role disease; disease; novel tmem173 ... See more keywords