Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28064
Abstract: Human immunodeficiency virus (HIV) capsid (CA) protein is a promising target for developing novel anti‐HIV drugs. Starting from highly anticipated CA inhibitors PF‐74, we used scaffold hopping strategy to design a series of novel 1,2,4‐triazole… read more here.
Keywords: capsid protein; novel triazole; hiv; hiv capsid ... See more keywords
Novel 1,2,4-triazole analogues as mushroom tyrosinase inhibitors: synthesis, kinetic mechanism, cytotoxicity and computational studies
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10102-5
Abstract: We have created a novel series of mushroom tyrosinase inhibitors with 1,2,4-triazole as fundamental skeleton. The target compound 1,2,4-triazol-3-ylthio)- N -phenyl acetamide derivatives 9(a–l) were synthesized by the reaction of 4- and 5-substituted 1,2,4-triazole-3-thiol derivatives… read more here.
Keywords: tyrosinase inhibitors; tyrosinase; mushroom tyrosinase; cytotoxicity ... See more keywords
Organocopper-based magnetically recoverable and reusable nanocatalyst for efficient synthesis of novel 1,2,3-triazole-based sulfonamides in green medium
Sign Up to like & getrecommendations! Published in 2017 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-017-3122-1
Abstract: Abstract We report robust green synthesis of novel 1,2,3-triazole-based sulfonamides bearing different motifs such as fluorine under click conditions in presence of a copper-based magnetically recoverable and reusable heterogeneous nanocatalyst. The organocopper catalyst at 0.5 mol.%… read more here.
Keywords: synthesis novel; based sulfonamides; based magnetically; triazole based ... See more keywords
Design, synthesis and biological evaluation of novel 1,2,3-triazole-based xanthine derivatives as DPP-4 inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-020-1760-0
Abstract: Abstract Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. A series of novel 1,2,3-triazole based xanthine derivatives were designed and evaluated for in vitro dipeptidyl peptidase-4 (DPP-4)… read more here.
Keywords: based xanthine; xanthine derivatives; dpp inhibitors; triazole based ... See more keywords
Design, synthesis, and in vitro evaluation of novel triazole analogues featuring isoxazole moieties as antifungal agents.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103982
Abstract: In order to develop novel antifungal agents, based on our previous work, a series of (2R,3R)-3-((3-substitutied-isoxazol-5-yl)methoxy)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl) butan-2-ol (a1-a26) were designed and synthesized. All of the compounds exhibited good in vitro antifungal activities against eight human… read more here.
Keywords: design synthesis; antifungal agents; evaluation novel; vitro evaluation ... See more keywords
The spectroscopic and computational investigation on interaction of a novel 1,2,3-triazole with three globular proteins
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Luminescence"
DOI: 10.1016/j.jlumin.2018.09.065
Abstract: Abstract The structural properties including quantum chemical parameters and theoretical spectrum of a newly synthesized compound, ethyl 5-phenyl-2-(o-tolyl)-2H-1,2,3- triazole-4-carboxylate (EPTC) have been investigated using GaussView5.0 program package and the time dependent density functional theory (TD… read more here.
Keywords: investigation interaction; interaction novel; globular proteins; computational investigation ... See more keywords
Efficient synthesis and DFT analysis of novel 1,2,3-triazole-based dithiocarbamates
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129535
Abstract: Abstract Novel 1,2,3-triazole-dithiocarbamate hybrids were synthesized in moderate to good yields (60–75%) in green solvent system H2O/t-BuOH by click azide‒alkyne [3 + 2] cycloaddition reaction with avoiding isolation and handling of hazardous organic azides. The structure of… read more here.
Keywords: efficient synthesis; analysis; dft; novel triazole ... See more keywords
Synthesis of novel 1,2,3-triazole based polycarboxylic acid functionalised ligands for MOF systems
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.01.014
Abstract: Abstract Copper catalysed click reactions are excellent tools to generate various 1,2,3-triazole linked polytopic aromatic carboxylates. The general reaction route involves protection of the carboxylates before proceeding with the click reaction. These polycarboxylate azoles are… read more here.
Keywords: triazole; based polycarboxylic; triazole based; structure ... See more keywords
Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00016
Abstract: The specificity of nucleic acids' binders is crucial for developing this kind of drug, especially for novel G-quadruplexes' binders. Quindoline derivatives have been developed as G-quadruplex stabilizers with good interactive activities. In order to improve… read more here.
Keywords: myc quadruplex; derivatives myc; chemistry; discovery novel ... See more keywords
Novel triazole-modified chitosan@nickel nanoparticles: efficient and recoverable catalysts for Suzuki reaction
Sign Up to like & getrecommendations! Published in 2017 at "New Journal of Chemistry"
DOI: 10.1039/c6nj03789e
Abstract: We have developed an efficient strategy to prepare uniformly sized spherical NiNPs supported on chitosan surface via click chemistry. This heterogeneous catalyst has demonstrated promising catalytic activity for the Suzuki–Miyaura coupling. Furthermore, the obtained catalyst… read more here.
Keywords: triazole modified; chitosan nickel; chemistry; modified chitosan ... See more keywords
Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones
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DOI: 10.3390/antiox12010036
Abstract: Herein, we report the synthesis and antioxidant capacity of twelve novel 1,2,3-triazole-containing nitrones such as N-(2-(4-aryl-1H-1,2,3-triazol-1-yl)ethylidene)methanamine oxides 8a–f and N-(2-(4-aryl)-1H-1,2,3-triazol-1-yl)ethylidene)-2-methylpropan-2-amine oxides 9a–f, bearing an N-methyl, and an N-t-butyl substituent, respectively, at the nitrogen of the… read more here.
Keywords: novel triazole; methylphenyl; synthesis antioxidant; fluoro methylphenyl ... See more keywords