Novel Tricyclic Compounds as KRAS Inhibitors for Treating Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00140
Abstract: Provided herein are novel tricyclic compounds as KRAS inhibitors, pharmaceutical compositions, use of such compounds in treating cancer and processes for preparing such compounds. read more here.
Keywords: kras inhibitors; novel tricyclic; treating cancer; tricyclic compounds ... See more keywords
Novel Tricyclic Compounds for Treating Bacterial Infections.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00289
Abstract: Provided herein are novel tricyclic compounds, pharmaceutical compositions, use of such compounds in treating bacterial infections, and processes for preparing such compounds. read more here.
Keywords: treating bacterial; chemistry; compounds treating; novel tricyclic ... See more keywords
Novel Tricyclic 2-Alkoxy-8-methyl-6-(pyrrolidin-1-yl)-4H-[1,2,4]triazolo[5,1-f]purine Derivatives: Synthesis and Characterization
Sign Up to like & getrecommendations! Published in 2020 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2020.1852287
Abstract: A convenient approach for the synthesis of diversely functionalized [1,2,4]triazolo[5,1-f]purine heterocyclic framework have been accomplished. The products were obtained through the combination of... read more here.
Keywords: triazolo; triazolo purine; alkoxy methyl; novel tricyclic ... See more keywords
Synthesis of Novel Tricyclic N-Acylhydrazones as Tubulin Polymerization Inhibitors
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26189212
Abstract: A series of N-acylhydrazones bearing a 1,4-dihydroindeno[1,2-b]pyrrole ring, along with benzene and thiophene rings substituted with chlorine or methyl groups, was synthesized and evaluated for their antiproliferative and cytotoxic activity against the melanoma A375 cell… read more here.
Keywords: synthesis novel; novel tricyclic; tubulin polymerization; polymerization ... See more keywords