Facile synthesis of novel 3,4,5-trisubstituted-1,2,4-triazin-6(1H)-ones via a sequential Ugi–Smiles type/nucleophilic substitution/cyclization reaction
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DOI: 10.1039/c8nj03949f
Abstract: A simple and innovative strategy is described for synthesizing a library of novel 3,4,5-trisubstituted-1,2,4-triazin-6(1H)-one backbones in mild conditions. This approach involves multiple bond-forming events in an Ugi–Smiles type reaction and the post-condensation of the Ugi–Smiles… read more here.
Keywords: novel trisubstituted; smiles type; reaction; trisubstituted triazin ... See more keywords
Design, synthesis, characterization, photophysical and pH chemosensor studies of novel 2,4,6-trisubstituted pyridines
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DOI: 10.1080/00397911.2017.1410174
Abstract: ABSTRACT For the application in organic electronics as well as pH meters, a series of novel 2,4,6-trisubstituted pyridines have been synthesized by the reaction of substituted aromatic aldehydes and substituted 3-acetylcoumarin with ammonium acetate. The… read more here.
Keywords: design synthesis; trisubstituted pyridines; photophysical chemosensor; novel trisubstituted ... See more keywords
Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells
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DOI: 10.1080/14756366.2022.2127700
Abstract: Abstract Multidrug resistance (MDR) is a leading cause for treatment failure in cancer patients. One of the reasons of MDR is drug efflux by ATP-binding cassette (ABC) transporters in eukaryotic cells especially ABCB1 (P-glycoprotein). In… read more here.
Keywords: cancer cells; novel trisubstituted; multidrug resistance; trisubstituted benzimidazole ... See more keywords
Crystal Structures and Optical Properties of Two Novel 1,3,5-Trisubstituted Pyrazoline Derivatives
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DOI: 10.3390/cryst8120467
Abstract: Two novel 1,3,5-trisubstituted pyrazoline derivatives—1-acetyl-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphthyl)-pyrazoline (2a) and 1-(4-nitrophenyl)-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphtyl)-pyrazoline (2b)—were synthesized and their structures were determined by single crystal X-ray crystallography. Both of the two crystals exhibit twisted structures due to the large dihedral angles between… read more here.
Keywords: novel trisubstituted; pyrazoline derivatives; trisubstituted pyrazoline; properties two ... See more keywords